PMID: 11920468Mar 29, 2002Paper

Cyclical change of hMSH2 protein expression in normal endometrium during the menstrual cycle and its overexpression in endometrial hyperplasia and sporadic endometrial carcinoma

Cancer
Atia A HamidShingo Fujii

Abstract

The role of hMSH2 protein, one of the major DNA repair proteins, until now, had not been elucidated in terms of normal endometrial function during the menstrual cycle. The current study was designed to address this issue and to determine whether the expression of hMSH2 is altered in the course of endometrial carcinogenesis. Immunohistochemical reactivity with a monoclonal antibody against the hMSH2 protein was examined in endometrial tissue specimens from 45 patients with normal endometrium, 51 patients with endometrial hyperplasia, and 27 patients with endometrial carcinoma. Immunohistochemical expression of proliferating cell nuclear antigen (PCNA) also was studied in the same samples as a measure of the proliferative activity and was compared with hMSH2 expression in each sample. The functional layer of normal endometrium displayed cyclic changes in hMSH2 protein expression during the menstrual cycle, showing positive expression in the proliferative phase and becoming weak to negative in the secretory phase. This expression pattern was similar to that of PCNA. Sixty-three percent of endometrial carcinomas showed strong positivity for both hMSH2 and PCNA expression, and 7.4% had an intensity of hMSH2 protein expression simila...Continue Reading

Citations

Sep 12, 2013·Journal of Gastrointestinal Cancer·Meysam MoghbeliMohammad Reza Abbaszadegan
Jun 6, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Kimberly H AllisonRochelle L Garica
Jul 6, 2007·The Journal of Investigative Dermatology·Markus SeifertJörg Reichrath
Oct 22, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Jen-Chung KoYun-Wei Lin
Mar 1, 2005·Virchows Archiv : an International Journal of Pathology·Pavlína PlevováZdenek Kolár

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