PMID: 16632761Apr 25, 2006Paper

Cyclical tensile force on periodontal ligament cells inhibits osteoclastogenesis through OPG induction

Journal of Dental Research
H KanzakiH Mitani

Abstract

The periodontal ligament (PDL) maintains homeostasis of periodontal tissue under mechanical tensile-loading caused by mastication. Occlusal load inhibits atrophic alveolar bone resorption. Previously, we discovered that continuous compressive force on PDL cells induced osteoclastogenesis-supporting activity, with up-regulation of RANKL. We hypothesized that, unlike compression, cyclical tensile force up-regulates OPG expression in PDL cells via TGF-beta up-regulation, and does not induce osteoclastogenesis-supporting activity. PDL cells were mechanically stimulated by cyclical tensile force in vitro. The conditioned media of PDL cells that had been subjected to cyclical tensile force inhibited osteoclastogenesis. Cyclical tensile force up-regulated not only RANKL mRNA expression, but also OPG mRNA expression in PDL cells. Tensile force up-regulated TGF-beta expression in PDL cells as well. Administration of neutralizing antibodies to TGF-beta inhibited OPG up-regulation under cyclical tensile-force stimulation in a dose-dependent manner. Additionally, the osteoclastogenesis-inhibitory effect of the conditioned media of PDL cells under cyclical tensile force was partially rescued by the administration of TGF-beta neutralizing an...Continue Reading

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Citations

Dec 6, 2011·Journal of Orofacial Orthopedics = Fortschritte Der Kieferorthopädie : Organ/official Journal Deutsche Gesellschaft Für Kieferorthopädie·Jianping ZhouHongwei Dai
Nov 30, 2011·TheScientificWorldJournal·Shahrul Hisham Zainal AriffinZaidah Zainal Ariffin
Nov 15, 2013·International Journal of Dentistry·A NiklasP Römer
Jan 12, 2016·Journal of Periodontal Research·J ManokawinchokeT Osathanon
Jun 22, 2011·Journal of Endodontics·Javier Caviedes-BucheliHugo Roberto Munoz
Apr 20, 2011·Periodontology 2000·Prasit Pavasant, Tussanee Yongchaitrakul
Jul 16, 2009·Journal of Periodontal Research·K NozakiH Miura
Mar 5, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Hsiao-Chi YuKurt Ming-Chao Lin
Nov 2, 2016·The Angle Orthodontist·Yayoi MatsudaKotaro Tanimoto
Dec 24, 2017·Photochemistry and Photobiology·Viviane JettarAguinaldo S Garcez
Mar 14, 2019·Journal of Periodontal Research·Jana MarciniakMichael Wolf
Sep 6, 2012·Journal of Cellular Biochemistry·Zhang Qing HongLiu Li
Jan 8, 2013·International Journal of Molecular Medicine·Sumika KameyamaJunichiro Iida
Oct 26, 2016·Molecular Medicine Reports·Masaaki IkedaJunichiro Iida
May 20, 2020·Scientific Reports·Yehuda KleinStella Chaushu
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May 2, 2019·BMC Molecular and Cell Biology·Hiroyuki KanzakiYoshiki Nakamura
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Mar 16, 2016·Journal of Tissue Engineering·Hye-Sun YuIvan Wall
Feb 7, 2018·Archives of Oral Biology·Nunthawan NowwaroteThanaphum Osathanon

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