Cyclin A is associated with an unfavourable outcome in patients with non-small-cell lung carcinomas

British Journal of Cancer
M VolmG Stammler

Abstract

Specimens of formalin-fixed, paraffin-embedded non-small-cell lung carcinomas (NSCLCs; n = 187) were analysed immunohistochemically for expression of cyclin A. The analysis was intended to determine whether cyclin A has additional prognostic value for predicting patients' survival and drug response. Of the 187 NSCLCs, 141 cases (75%) showed expression of cyclin A. Patients with cyclin A-positive carcinomas had significantly shorter median survival times than patients with cyclin A-negative carcinomas (79 vs 129 weeks, P = 0.045). Similar results were obtained with more homogeneous groups of patients: patients with only T3 tumours, patients with epidermoid carcinomas and patients with lymph node involvement. The clinical parameters (age, stage, histology, extent of tumour size, lymph node involvement) had no influence on expression of cyclin A. A direct correlation between cyclin A and the proportion of S-phase cells (P = 0.08) and an inverse relationship between cyclin A and the proportion of G0/G1-phase cells (P = 0.04) were found. Furthermore, a significant correlation between the expression of cyclin A and the response of NSCLC to doxorubicin in vitro was detected (P = 0.026).

Citations

Aug 31, 1999·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M YasunagaN Kitamura
Sep 27, 2003·Expert Review of Molecular Diagnostics·Amber YasmeenCarsten Müller-Tidow
Feb 9, 2010·Cell Adhesion & Migration·Beatrice Eymin, Sylvie Gazzeri
Jun 17, 1999·International Journal of Cancer. Journal International Du Cancer·Y L ZhaiS Fujii
Mar 1, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Hiromichi NakabayashiMitsuhiro Hara
May 19, 2006·International Journal of Cancer. Journal International Du Cancer·Johanna MrenaAri Ristimäki
Dec 24, 2009·Gastroenterology Research and Practice·Rolf AamodtIda R K Bukholm
Jan 1, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shinogu TakashimaYoshihiro Minamiya
Jun 15, 2020·Journal of Molecular Neuroscience : MN·Yuduo GuoChunjiang Yu
Feb 14, 2004·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Virve KoljonenTom Böhling
Nov 8, 2003·World Journal of Gastroenterology : WJG·Qi ZhouLi-Jian Liang
Aug 11, 2005·British Journal of Cancer·P PoikonenC Blomqvist
Mar 4, 2005·Pathology International·Yoh Dobashi
Aug 12, 2003·Breast Cancer Research and Treatment·Ida R K BukholmGeir Bukholm
Aug 17, 2000·The Journal of Veterinary Medical Science·Y MurakamiR Yamaguchi
Sep 30, 2010·Immunotherapy·Nela Klein-GonzálezMichael S von Bergwelt-Baildon
Jun 28, 2011·International Journal of Cancer. Journal International Du Cancer·Chang NiuQinong Ye
Mar 26, 2011·Expert Review of Vaccines·Michael S von Bergwelt-BaildonClemens M Wendtner
Jun 21, 2005·Journal of Cellular Physiology·Mario CaputiAntonio Giordano
Mar 24, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·William SterlacciAlexandar Tzankov
Feb 15, 2000·American Journal of Respiratory and Critical Care Medicine·Y HirasawaM Miyake
Feb 12, 2002·Photochemistry and Photobiology·Arianna L KimJean Gautier
Dec 30, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria Rodriguez-PinillaMontserrat Sanchez-Cespedes
May 8, 2014·Cancer Research·Lakshmi GopinathanPhilipp Kaldis
Dec 20, 2015·Molecular Cancer Research : MCR·Rakesh DachineniG Jayarama Bhat
Jun 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil SinghalSteven M Albelda
Feb 12, 2004·Cancer Research·Ulrike KronenwettGert Auer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.