Abstract
Cyclin A is a cell cycle regulatory protein that functions in mitotic and S phase control in mammalian cells. However, in contrast to other G1 phase regulatory proteins, such as cyclin D, retinoblastoma protein and p16INK4A, cyclin A seems not to be commonly involved in tumorigenesis. Recently, a second human cyclin A--cyclin A1--has been identified. In contrast to cyclin A which is expressed throughout embryonic development and in adult tissue, the expression of cyclin A1 has been reported to be restricted to embryonic and germ line cells. We have confirmed the absence of cyclin A1 mRNA from normal peripheral blood leukocytes of seven healthy donors by single step reverse transcriptase-polymerase chain reaction (RT-PCR). Furthermore, we have examined the expression of cyclin A1 mRNA in 173 peripheral blood samples of 162 patients with various hematological malignancies. Cyclin A1 mRNA was detectable in 11 of 11 patients with acute myeloid leukemia, three of three patients with acute biphenotypic leukemia, eight of eight patients with myelodysplastic syndrome, 59 of 69 patients with chronic myelogenous leukemia (CML) at diagnosis, 13 of 15 patients with CML in blastic transformation, 10 of 18 patients with chronic lymphocytic l...Continue Reading
Citations
Jan 22, 2003·Cancer Letters·Carsten Müller-TidowHubert Serve
Aug 12, 2009·Oncogene·C B ChanK Ye
Jun 25, 2004·Biology of Reproduction·Karen M Lele, Debra J Wolgemuth
Jun 19, 2008·Cancer Research·Sung-Wuk JangKeqiang Ye
Feb 8, 2007·Blood·Luke F PetersonDong-Er Zhang
Mar 30, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Tiffany van der MeerWilliam H Colledge
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·C LiaoD J Wolgemuth
Jun 7, 2008·Hematology·Ana VidovićDarinka Bosković
Apr 24, 2001·Environmental and Molecular Mutagenesis·C R GiverM G Pallavicini
Feb 24, 2016·Genomics·M Andrea MarkusBrian J Morris
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Ching LiaoDebra J Wolgemuth
Nov 22, 2007·International Journal of Cancer. Journal International Du Cancer·Barbara WegielJenny Liao Persson
Sep 27, 2005·Leukemia Research·Caroline HolmJenny Liao Persson
Aug 17, 2005·Leukemia Research·M GolemovićD Batinić
Sep 27, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kuan-Chun HuangShu-Wing Ng
Oct 19, 2004·Oncogene·Jenny EkbergJenny Liao Persson
Apr 25, 2007·International Journal of Cancer. Journal International Du Cancer·Ping JiCarsten Müller-Tidow
Jul 12, 2005·European Journal of Haematology·Jenny EkbergJenny Liao Persson
Dec 8, 1998·Nature Genetics·D LiuD J Wolgemuth
Oct 31, 2002·Blood·Jörg CammengaStephen D Nimer
Jan 28, 2020·Blood Advances·Wingchi K LeungPremal Lulla
Oct 9, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mauricio S CaetanoJoão P B Viola
May 13, 2008·Molecular and Cellular Biochemistry·Qingsheng Yu, Ji Wu
Jul 11, 2019·Oncology Letters·Xiaoting HeXiufeng Cao
May 6, 2020·Scientific Reports·Lenka RadonovaMartin Anger
Jul 5, 2006·Cancer Research·Akiko TakedaNabeel R Yaseen