Cyclin A1 regulates the interactions between mouse haematopoietic stem and progenitor cells and their niches

Cell Cycle
Regina MiftakhovaJenny L Persson

Abstract

It remains poorly understood how the haematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction. In the absence of cyclin A1, the HSPC in the BM are increased in their frequency and display an increased migratory and homing ability. Concomitantly, the ability of the endosteal and central BM niche zones to attract and home the wild-type HSPC is significantly reduced in cyclin A1-null mice as compared to the wild-type controls. The impaired proliferation and homing of HSPC in the BM of cyclin A1-null mice are attributed to the increased density of microvessels in the endosteal and central BM niche zones, which is associated with the increased VEGFR1 expression. Thus, modulation of cyclin A1 and VEGFR1 in HSPC and their niches may provide new insights into therapeutic approaches.

References

Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S J SzilvassyC J Eaves
Dec 8, 1998·Nature Genetics·D LiuD J Wolgemuth
Mar 22, 2000·Circulation Research·S Dimmeler, A M Zeiher
Sep 23, 2000·Nature·G D YancopoulosJ Holash
Jun 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·C LiaoD J Wolgemuth
Oct 24, 2003·Nature·L M CalviD T Scadden
Dec 30, 2003·International Journal of Cancer. Journal International Du Cancer·Ching LiaoDebra J Wolgemuth
Feb 24, 2006·Nature Reviews. Immunology·Anne Wilson, Andreas Trumpp
May 4, 2006·The Journal of Clinical Investigation·Tong Yin, Linheng Li
Jul 1, 2006·Nature·David T Scadden
Jul 10, 2008·Journal of the National Cancer Institute·Barbara WegielJenny Liao Persson
Jun 6, 2009·Cell Stem Cell·Russell W Garrett, Stephen G Emerson
Oct 3, 2009·Annals of the New York Academy of Sciences·Hans-Georg KoppShahin Rafii
Nov 6, 2009·The Journal of Experimental Medicine·Deepta BhattacharyaIrving L Weissman
Apr 16, 2010·Annals of the New York Academy of Sciences·Stefania LymperiDavid T Scadden
Jun 16, 2011·Blood·Sarah L EllisSusan K Nilsson
Oct 26, 2012·The FEBS Journal·Leyuan BaoSreenivasan Ponnambalam
Jan 17, 2014·Nature·Sean J Morrison, David T Scadden

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Citations

Jul 1, 2015·Cell Cycle·Niels Ødum
Jun 19, 2012·Cell Stem Cell·Michael R CopleyConnie J Eaves
Jun 28, 2012·Gynecologic Oncology·Xuxian XiaoZhi-Xiang Xu
Mar 1, 2012·Molecular and Cellular Endocrinology·Morgan D FullertonJonathan D Schertzer
May 28, 2015·Biochimica Et Biophysica Acta·Kati J AhlqvistRiikka H Hämäläinen
Jul 2, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Hakmo LeeKyong Soo Park
Mar 15, 2019·Experimental and Therapeutic Medicine·Yiyun Tan, Lei Liu
Aug 27, 2021·Journal of Cellular Physiology·Giuliana ManninoDebora Lo Furno

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Methods Mentioned

BETA
FACS
confocal microscopy
PCR
fluorescence-activated cell sorting
flow cytometric cell sorting
FCS
flow cytometry
Electrophoresis

Software Mentioned

DeNovo
Graphpad
FCS Express
FlowJo

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