PMID: 8594075Oct 1, 1995Paper

Cyclin D and retinoblastoma gene product expression in actinic keratosis and cutaneous squamous cell carcinoma in relation to p53 expression

Journal of Cutaneous Pathology
T BitoM Ichihashi

Abstract

Abnormality of the molecules regulating the cell cycle has been shown to lead cells to transformation. Recently, overexpression of cyclin D protein, one of the G1 cyclins, and the abnormality of the retinoblastoma gene have been found in various human cancers. We analyzed the expression of cyclin D, retinoblastoma gene product (pRB) and p53 in actinic keratoses (AKs) and cutaneous squamous cell carcinomas (SCCs) by immunohistochemistry to elucidate the role of these molecules in keratinocyte carcinogenesis. In the normal epidermis, a few cyclin D positive cells were seen mainly at the basal layer. In 11 seborrheic keratoses, no overexpression of cyclin D was observed. Twelve of 26 AKs (46%) and 27 of 45 SCCs (60%) showed cyclin D overexpression. A few pRB positive cells were seen in the basal layer and in the suprabasal spinous layer of the normal epidermis. An abnormality of pRB, loss of expression, was seen in 2 of 26 AKs (8%) and 7 of 45 SCCs (16%). p53 protein was positive in 12 of 26 AKs (46%) and 24 of 45 SCCs (53%). Forty-five SCCs examined were divided into 22 ultraviolet (UV)-related SCCs and 23 UV-unrelated SCCs. Though UV-related SCCs showed a significantly higher incidence of p53 positivity, as previously reported b...Continue Reading

References

Jun 1, 1991·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S R ShiK L Kalra
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E BrashJ Pontén
Jan 1, 1991·Molecular Carcinogenesis·W E PierceallH N Ananthaswamy
Dec 22, 1994·Nature·A ZieglerD E Brash
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·I E SchauerR A Sclafani
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·H NakazawaH Yamasaki

❮ Previous
Next ❯

Citations

May 21, 2003·Archives of Dermatological Research·Andrija StanimirovićMladen Belicza
Jan 29, 2010·Journal of Bone and Mineral Metabolism·Daniel D Bikle
Aug 17, 2011·Reviews in Endocrine & Metabolic Disorders·Daniel D Bikle
Sep 20, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Daniel D Bikle
Apr 1, 1997·Journal of Cutaneous Pathology·N U AhmedM Ichihashi
Aug 3, 2010·International Journal of Radiation Biology·Akihisa TakahashiTakeo Ohnishi
Apr 21, 2009·The Journal of Surgical Research·Vanessa JensenRobert S Krouse
Sep 13, 2008·The Journal of Investigative Dermatology·Daniel D Bikle
Jul 7, 2012·Journal of Cutaneous Pathology·Crystal L RoseMichael T Tetzlaff
Sep 10, 2015·Journal of Cutaneous Pathology·Dimitrije BrasanacEmilija Manojlovic-Gacic
Jan 28, 1999·Journal of the American Academy of Dermatology·S R FeldmanJ L Jorizzo
Oct 13, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Daniel D BikleArnaud Teichert
Jan 7, 2015·Canadian Journal of Physiology and Pharmacology·Daniel D Bikle
Feb 12, 2002·Photochemistry and Photobiology·Arianna L KimJean Gautier
Feb 11, 2005·Journal of Cutaneous Pathology·Mahmoud R Hussein
Jan 13, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·D TomasM Belicza
Nov 10, 2013·Cancers·Daniel D Bikle, Yan Jiang
Dec 10, 1997·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R A Schwartz
Nov 10, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Thomas J KnackstedtFaramarz H Samie
Mar 2, 2017·Apoptosis : an International Journal on Programmed Cell Death·Hui-Ping ChenYan Xu
Nov 4, 2005·Cancer Research·Sergio RuizJesús M Paramio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Journal of Cellular Biochemistry
Pamela Renate MollKlaus Richter
Journal of Cutaneous Pathology
N U AhmedM Ichihashi
Journal of the European Academy of Dermatology and Venereology : JEADV
C LagunaV Alegre
Journal of the European Academy of Dermatology and Venereology : JEADV
K NamikawaF Otsuka
© 2021 Meta ULC. All rights reserved