PMID: 11920603Mar 29, 2002Paper

Cyclin D1 amplification in chromosomal band 11q13 is associated with overrepresentation of 3q21-q29 in head and neck carcinomas

International Journal of Cancer. Journal International Du Cancer
Yuesheng JinFredrik Mertens

Abstract

Eight cytogenetically characterized head and neck squamous cell carcinomas (HNSCCs) with CCND1 amplification in the form of a homogeneously staining region (hsr) in 11q13 were studied by COBRA FISH and FISH with specific probes to identify and characterize chromosomal segments added to the derivative chromosomes 11. In 4 of the tumors, it could be recognized that the material added was derived from the long arm of chromosome 3. The rearrangements were interpreted as der(11)hsr(11)(q13)t(3;11)(q21;q13) in 3 cases and as der(11)hsr(11)(q13)t(3;11)(q14;q13) in 1 case. In the other 4 cases, material from chromosomes 1, 16, or 19 was added to the derivative chromosomes 11. By further FISH analysis with 14 YAC clones spanning 3q13-q21 in the 4 tumors with der(11)hsr(11)t(3;11), it could be shown that they had different breakpoints at the molecular level, excluding the possibility that a particular gene was rearranged by the translocations. More surprisingly, gain of the 3q21-q29 segment was found in all 8 tumors with hsr in 11q13 and loss of 3p was seen in 7 of the tumors. These findings strongly indicate a synergistic effect of CCND1 amplification, loss of distal 11q, 3q gain and 3p deletion in HNSCC development and also suggests a ...Continue Reading

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Citations

Jun 14, 2005·Cancer Genetics and Cytogenetics·Małgorzata JarmuzKrzysztof Szyfter
Oct 22, 2013·Genes, Chromosomes & Cancer·Rahul A ParikhSusanne M Gollin
Dec 14, 2004·Cancer Genetics and Cytogenetics·Yuesheng JinYok-Lam Kwong
Dec 21, 2005·Cancer Genetics and Cytogenetics·Charlotte JinFredrik Mertens
Apr 28, 2006·Nature·Donna M MuznyRichard A Gibbs
Mar 15, 2006·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Hina SheikhJennifer L Hunt

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