Cyclin D1 and p16 Expression in Blue Nevi and Malignant Melanoma

Applied Immunohistochemistry & Molecular Morphology : AIMM
Jessica M DoniganChristopher Lum

Abstract

Differentiating benign blue nevi from blue nevus-like melanoma can be diagnostically challenging. We aimed to determine the utility of immunohistochemical staining for p16 and cyclin D1 in distinguishing benign blue nevi and malignant melanoma. Thirty-two biopsy specimens taken between 2007 and 2015 were obtained from the Department of Pathology at the Queen's Medical Center in Honolulu, HI. These included 9 common blue nevi, 8 cellular blue nevi (2 with atypical features), and 15 malignant melanomas (3 blue nevus-like melanoma). The primary outcome was the difference in p16 and cyclin D1 staining between benign blue nevi and malignant melanoma. Staining of specimens for p16 and cyclin D1 was graded on the strength of staining, and the percent of tumor that stained positive. A specimen was deemed positive if it showed 2+ staining in ≥50% of the tumor. The majority (82%) of blue nevi stained negative for p16. There was not a significant difference between p16 staining in benign blue nevi and melanoma (P=0.06). Eleven (73%) melanomas stained positive for cyclin D1 with a sensitivity of 0.73 and positive predictive value of 1.0. All blue nevi were negative for cyclin D1, making its specificity 1.0 and its negative predictive value...Continue Reading

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Citations

Jun 26, 2018·Archives of Pathology & Laboratory Medicine·Stephen S Koh, David S Cassarino
Sep 11, 2019·Veterinary and Comparative Oncology·Clarissa ZamboniMassimo Castagnaro
Apr 25, 2020·Journal of Cutaneous Pathology·Gabriel OaxacaJennifer S Ko
Mar 10, 2020·Pigment Cell & Melanoma Research·Lucia González-RuizPablo Ramos-García

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