PMID: 9449484Feb 4, 1998Paper

Cyclin D1 and retinoblastoma protein expression in Kaposi's sarcoma

Journal of Cutaneous Pathology
M G HorensteinD C Louie

Abstract

Cyclins are implicated in the induction and control of the cell cycle. Cyclin D1 regulates G1-phase progression by phosphorylation of the retinoblastoma protein (pRb). The Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV) contains and transcribes an open reading frame with sequence similarities to cellular D-type cyclins. The KSHV-cyclin protein is associated with kinase activity capable of phosphorylating pRb in vitro. Here, we study for the first time the endogenous cyclin D1 and Rb protein expression in Kaposi's sarcoma (KS) tissue. Twenty-four consecutive biopsies of AIDS-related (n=21) and classical (n=3) KS were studied by immunohistochemistry with monoclonal antibodies against cyclin D1 and pRb. We detected cyclin D1 in 1 of 13 patch/plaque stage, in 4 of 5 nodular stage and in 3 of 6 visceral KS lesions. By Western blot analysis, this cellular cyclin D1 monoclonal antibody did not cross-react with the purified KSHV-cyclin protein. The pRb was consistently detected in 24 of 24 KS lesions. In summary, early KS lesions rarely have detectable expression of endogenous cyclin D1. Advanced and disseminated KS lesions tend to have overexpression of endogenous cyclin D1. Therefore, cellular cyclin D1 expression ...Continue Reading

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Citations

May 15, 2004·DNA and Cell Biology·Shohreh AminiBassel E Sawaya
Dec 31, 2009·Glycobiology·Donald J AlcendorGary S Hayward
Jun 23, 2001·The American Journal of Surgical Pathology·L A EricksonR V Lloyd
May 28, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Angela HongC Soon Lee
Jan 25, 2000·Journal of Clinical Pathology·M M KennedyJ J O'Leary
Jul 20, 1999·Dermatologic Clinics·V G Prieto, C R Shea
Mar 21, 2018·Cancers·Timsy UppalSubhash C Verma
Jul 25, 2014·Biomarkers in Cancer·Brian Thabile FlepisiBernd Rosenkranz
Nov 6, 2008·Journal of Cutaneous Pathology·Marcelo G HorensteinEthel Cesarman
Mar 4, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·L A EricksonR V Lloyd
Nov 14, 2020·Biochimica Et Biophysica Acta. Reviews on Cancer·Danyelle A FerreiraNigel A J McMillan
Aug 8, 2021·International Journal of Molecular Sciences·Zodwa DlaminiRahaba Marima

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