Cyclin D1 binds the androgen receptor and regulates hormone-dependent signaling in a p300/CBP-associated factor (P/CAF)-dependent manner

Molecular Endocrinology
A T ReutensR G Pestell

Abstract

The androgen receptor (AR) is a ligand-regulated member of the nuclear receptor superfamily. The cyclin D1 gene product, which encodes the regulatory subunit of holoenzymes that phosphorylate the retinoblastoma protein (pRB), promotes cellular proliferation and inhibits cellular differentiation in several different cell types. Herein the cyclin D1 gene product inhibited ligand-induced AR- enhancer function through a pRB-independent mechanism requiring the cyclin D1 carboxyl terminus. The histone acetyltransferase activity of P/CAF (p300/CBP associated factor) rescued cyclin D1-mediated AR trans-repression. Cyclin D1 and the AR both bound to similar domains of P/CAF, and cyclin D1 displaced binding of the AR to P/CAF in vitro. These studies suggest cyclin D1 binding to the AR may repress ligand-dependent AR activity by directly competing for P/CAF binding.

Citations

Jan 15, 2009·Nature Reviews. Cancer·Erik S Knudsen, Karen E Knudsen
Dec 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Eugenia CifuentesG Prem-Veer Reddy
Mar 26, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jin T E LimI Bernard Weinstein
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Craig J BurdKaren E Knudsen
Jul 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Chenguang WangRichard G Pestell
May 21, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sook Shin, Inder M Verma
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M StanbroughS P Balk
Jun 17, 2010·The Journal of Biological Chemistry·Tasneem Bawa-KhalfeEdward T H Yeh
Jan 8, 2011·The Journal of Biological Chemistry·Clay E S ComstockKaren E Knudsen
Jan 22, 2005·Molecular Biology of the Cell·Frédéric BienvenuOlivier Coqueret
Aug 23, 2006·Molecular and Cellular Biology·Maofu FuRichard G Pestell
Aug 19, 2007·Molecular and Cellular Biology·Hongliang ZongJianxin Gu
Aug 15, 2003·Molecular and Cellular Biology·Chenguang WangRichard G Pestell
Nov 13, 2003·Molecular and Cellular Biology·Maofu FuRichard G Pestell
Feb 7, 2012·The Journal of Clinical Investigation·Mathew C CasimiroRichard G Pestell
Dec 22, 2012·The Journal of Clinical Investigation·Michael A AugelloKaren E Knudsen
Jul 26, 2006·Cell Division·Karen E Knudsen
Jan 29, 2011·Molecular Endocrinology·Soyoung KoBandana Chatterjee
Oct 30, 2004·Genetics·Jan EmmerichChristian F Lehner
Nov 10, 2001·Trends in Endocrinology and Metabolism : TEM·L Altucci, H Gronemeyer
Apr 10, 2009·Endocrine-related Cancer·Gwen E DressingCarol A Lange
May 19, 2009·BMC Cancer·Ashwini L ChandColin D Clyne
Feb 27, 2010·Cellular and Molecular Life Sciences : CMLS·Tamzin M TannerAnnemie Haelens
Dec 21, 2010·The Journal of Steroid Biochemistry and Molecular Biology·Chenguang WangRichard G Pestell
Jan 9, 2007·Molecular and Cellular Endocrinology·N L Weigel, N L Moore
Jun 5, 2004·Biochemical and Biophysical Research Communications·Huei-Ju TingChawnshang Chang
Nov 5, 2011·International Journal of Cancer. Journal International Du Cancer·Ching-Yuan WuHong-Yo Kang
Jul 18, 2006·Biochemical Pharmacology·Jennifer E LeaderRichard G Pestell
Jul 2, 2015·Cancer Medicine·Kirsi M KaukoniemiTapio Visakorpi
Sep 6, 2002·Biochemical Pharmacology·James HulitRichard G Pestell
Jul 26, 2011·Molecular and Cellular Endocrinology·Matthew J SchiewerKaren E Knudsen
Jun 26, 2013·The American Journal of Pathology·Richard G Pestell
Jan 6, 2012·Biology of Reproduction·Carine RoyerCatarina S Porto
Dec 3, 2002·Gene·Olivier Coqueret
Dec 23, 2003·Journal of Cellular Biochemistry·Michael J Weber, Daniel Gioeli

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