Cyclin D1 expression in acute leukemia

Hematology
Salah ArefA Metwaly

Abstract

Disorders of the cell cycle regulatory machinery play a key role in the pathogenesis of cancer. Over expression of cyclin D1 protein has been reported in several solid tumors and certain lymphoid malignancies, but little is known about the involvement of cyclin D1 in acute leukemia. In this study, we analyzed the expression of cyclin D1 at protein level in, 40 newly diagnosed patients with acute myeloid leukemia (AML), 10 patients with acute lymphoblastic leukemia (ALL), and 11 normal controls using flow cytometry. The expression of cyclin D1 was not significantly different in AML group as compared to normal controls. On the other hand, over expression of cyclin D1 was evident in ALL group (4/10) as compared to that in healthy control. The ALL cases with cyclin D1 over expression were significantly correlated to blast cell counts in the peripheral blood and bone marrow (BM) but not with hemoglobin level, WBC, and platelets count. The ALL group with lymphadenopathy and organomegaly express significantly higher cyclin D1 over expression as compared to those without. The biological value of cyclin D1 over expression might be different in AML and ALL.

References

Nov 15, 2002·Cancer Biology & Therapy·J Alan Diehl
Apr 3, 2004·Trends in Molecular Medicine·Mark E Ewen, Justin Lamb
Aug 28, 2004·Endocrinology·Maofu FuRichard G Pestell

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Citations

Sep 4, 2012·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ghada M ElsayedManar M Moneer
Oct 24, 2009·The Journal of Biological Chemistry·Ping LaPhyllis A Dennery
Jul 8, 2008·BMC Systems Biology·Amira Djebbari, John Quackenbush
Dec 11, 2008·European Journal of Haematology·Katharina Salome MinkeKarl-Anton Kreuzer
May 8, 2008·The British Journal of Dermatology·X Mao, G Orchard
Aug 20, 2015·Saudi Journal of Biological Sciences·Archana JayaramanHaseeb A Khan
May 3, 2015·Leukemia Research·Géraldine GosseBrian T Wilhelm

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