PMID: 7540362Jun 1, 1995Paper

Cyclin D1 expression in non-Hodgkin's lymphomas. Detection by immunohistochemistry

American Journal of Clinical Pathology
L R ZukerbergN L Harris

Abstract

Cyclin D1/PRAD1 (bcl-1) is a recently discovered proto-oncogene that is overexpressed in mantle cell lymphomas and several other human tumors. In a previous study, the authors demonstrated expression of cyclin D1 in 15 of 15 cases of mantle cell lymphoma and 1 of 8 cases of B-chronic lymphocytic leukemia (B-CLL) using a polyclonal antibody and microwave enhanced immunohistochemical staining method on paraffin-embedded tissue sections. In this study, 107 additional B- and T-cell neoplasms were studied, including 47 cases of high grade lymphoma (33 diffuse large B-cell type, 9 Burkitt and Burkitt-like, 4 precursor T-lymphoblastic lymphoma, and 1 adult T-cell lymphoma/leukemia), 38 additional cases of low grade B-cell lymphoma (18 CLL, 15 hairy cell leukemia and 5 mantle cell lymphoma), and 22 plasmacytomas for expression of cyclin D1 using the same immunohistochemical staining technique. All cases of mantle cell lymphoma showed diffuse nuclear staining. No additional cases of CLL showed cyclin D1 expression. In contrast, 1 of 15 hairy cell leukemias and 1 of 22 plasmacytomas showed cyclin D1 staining. None of the high grade lymphomas demonstrated expression of cyclin D1 protein by immunostaining, including three cases of large B-...Continue Reading

Citations

Jun 30, 2000·American Journal of Clinical Pathology·J D HoyerP J Kurtin
Jan 5, 2002·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·J L FraterR R Tubbs
Sep 14, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·I T CangulT S G A M van den Ingh
Dec 1, 2007·Advances in Anatomic Pathology·Bharat N NathwaniMilton R Drachenberg
Aug 11, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·C C ChenS H Swerdlow
Jun 3, 1998·British Journal of Haematology·R FonsecaP R Greipp
Nov 4, 2000·Neurosurgery·M BarnardL C Ang
May 11, 2002·Leukemia & Lymphoma·Yuko HashimotoMasafumi Abe
Apr 6, 2005·Journal of Cancer Research and Clinical Oncology·Dorota DworakowskaEugenia Czestochowska
Aug 11, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·H W KorinM Younes
Mar 17, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sheila Aparecida Coelho SiqueiraPaulo Hilario Nascimento Saldiva
Jun 10, 2008·Current Opinion in Hematology·Mitchell R Smith
May 23, 2008·Histopathology·M Rodriguez-JustoC M Bacon
Jan 6, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R N MirandaJ B Cousar
Jul 11, 2001·Advances in Anatomic Pathology·E D Hsi, S Yegappan
May 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·L Jeffrey MedeirosRajyalakshmi Luthra
Oct 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M KremerF Fend
Dec 28, 1999·Leukemia & Lymphoma·R FonsecaP R Greipp
Jul 1, 1997·Pathology International·S NakamuraM Seto
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·E AthanasiouC S Papadimitriou
Jun 4, 2008·Histopathology·U ZanettoC M Bacon
Mar 18, 2009·American Journal of Clinical Pathology·Henry Y DongSorina Tugulea
Jun 15, 2014·The Journal of Endocrinology·H A SterleM L Barreiro Arcos
Apr 15, 2017·Journal of Clinical Pathology·Larissa Sena Teixeira MendesAndrew Wotherspoon
Dec 1, 1995·British Journal of Haematology·F BoschC Rozman
Nov 28, 2001·Hematology·N L HarrisW C Chan
Jul 19, 2006·Virchows Archiv : an International Journal of Pathology·Ioannis KostopoulosLorenzo Leoncini
Jun 14, 2017·Archives of Pathology & Laboratory Medicine·Huan-You Wang, Youli Zu
Aug 7, 2002·American Journal of Clinical Pathology·Zach LiuJames Weisberger
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·D S ViswanathaC P Leith
Jul 24, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Scott D BoydRoger A Warnke
Feb 2, 2002·Human Pathology·Steven H Swerdlow, Michael E Williams

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.