Cyclin D1 in human neuroblastic tumors recapitulates its developmental expression: An immunohistochemical study

Acta histochemica
Gaetano MagroRosalba Parenti

Abstract

The protein cyclin D1 (CD1), which belongs to a family of proteins functioning as regulators of CDKs (cyclin-dependent kinases) throughout the cell cycle, has been immunohistochemically detected in a wide variety of human malignant tumors. The aim of the present study was to investigate immunohistochemically the expression and distribution of CD1 in the developing human peripheral sympathetic nervous system (PSNS) and in childhood peripheral neuroblastic tumors (neuroblastomas, ganglioneuroblastomas, and ganglioneuromas). The above mentioned fetal and neoplastic tissues represent an in vivo model in which undifferentiated neuroblastic cells undergo ganglion cell differentiation. During development, a strong nuclear expression of CD1 was restricted to neuroblasts, disappearing progressively from the maturing ganglion cells with increasing gestational age. In neoplastic tissues, CD1 immunoreactivity was restricted to neuroblastic cell component of all neuroblastomas and ganglioneuroblastomas, whereas it was absent or only focally detectable in maturing/mature ganglion cell component of differentiating neuroblastomas, ganglioneuroblastomas, and ganglioneuromas. We conclude that CD1 is a reliable marker, which can be used routinely...Continue Reading

References

Apr 11, 1991·Nature·T MotokuraA Arnold
Feb 1, 1993·Journal of Neurobiology·M D GershonT P Rothman
Jul 1, 1995·Acta histochemica·G MagroC Emmanuele
May 1, 1996·The Histochemical Journal·G MagroM Lopes
Mar 21, 1998·The American Journal of Surgical Pathology·M MiettinenA Stevenson
Sep 15, 1998·The Korean Journal of Internal Medicine·W H KimJ K Ko
Jul 27, 1999·The Journal of Biological Chemistry·M J SpinellaE Dmitrovsky
Nov 15, 2002·Cancer Biology & Therapy·J Alan Diehl
Jan 31, 2003·Genes, Chromosomes & Cancer·Jan J MolenaarHuib N Caron
Dec 4, 2003·Oncogene·Piyamas SumrejkanchanakijMasa-Aki Ikeda
Apr 15, 2004·Journal of Mammary Gland Biology and Neoplasia·Robert L Sutherland, Elizabeth A Musgrove
Aug 28, 2004·Endocrinology·Maofu FuRichard G Pestell
Jan 6, 2006·Growth Factors·Elizabeth A Musgrove
Mar 22, 2006·Oncogene·K E KnudsenE S Knudsen
Jul 25, 2006·Cell Cycle·Kelly A McClellan, Ruth S Slack
Apr 13, 2007·Physiological Reviews·Preeti AhujaW Robb MacLellan
Feb 18, 2011·Thyroid : Official Journal of the American Thyroid Association·Gaetano MagroRoberto Perris
Aug 21, 2012·Canadian Journal of Physiology and Pharmacology·Adam HotchkissKishore B S Pasumarthi
May 2, 2013·Genes & Cancer·Mathew C CasimiroRichard G Pestell

❮ Previous
Next ❯

Citations

Oct 30, 2015·Acta histochemica·Paolo FagoneGaetano Magro
Apr 18, 2015·Acta histochemica·Lucia SalvatorelliGaetano Magro
Apr 11, 2015·Acta histochemica·Rosalba ParentiGaetano Magro
Apr 22, 2015·Acta histochemica·Gaetano MagroRosalba Parenti

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.