Mar 22, 2012

Cyclin D1 inactivation extends proliferation and alters histogenesis in the postnatal mouse retina

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Gaurav DasEdward M Levine

Abstract

The cell-cycle regulator Cyclin D1 is expressed in embryonic retinal progenitor cells (RPCs) and regulates their cell-cycle rate and neurogenic output. We report here that Cyclin D1 also has important functions in postnatal retinal histogenesis. The initial production of Müller glia and bipolar cells was enhanced in Cyclin D1 knockout (Ccnd1(-/-) ) retinas. Despite a steeper than normal rate of depletion of the RPC population at embryonic ages, postnatal Ccnd1(-/-) retinas exhibited an extended window of proliferation, neurogenesis, and gliogenesis. Cyclin D3, normally confined to Müller glia, was prematurely expressed in Ccnd1(-/-) RPCs. However, Cyclin D3 did not compensate for Cyclin D1 in regulating cell-cycle kinetics or neurogenic output. The data presented in this study along with our previous finding that Cyclin D2 was unable to completely compensate for the absence of Cyclin D1 indicate that Cyclin D1 regulates retinal histogenesis in ways not shared by the other D-cyclins.

  • References43
  • Citations8

Mentioned in this Paper

Embryo
Cyclin D2
Neuroglia
Cell Proliferation
Cell Differentiation Process
Retinaldehyde
Eye - Retina (Mmhcc)
Cyclins
Cyclin D1
Cell Cycle

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