Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis.

Cancer Cell
Rinath JeselsohnPhilip W Hinds

Abstract

Transplantation studies have demonstrated the existence of mammary progenitor cells with the ability to self-renew and regenerate a functional mammary gland. Although these progenitors are the likely targets for oncogenic transformation, correlating progenitor populations with certain oncogenic stimuli has been difficult. Cyclin D1 is required for lobuloalveolar development during pregnancy and lactation as well as MMTV-ErbB2- but not MMTV-Wnt1-mediated tumorigenesis. Using a kinase-deficient cyclin D1 mouse, we identified two functional mammary progenitor cell populations, one of which is the target of MMTV-ErbB2. Moreover, cyclin D1 activity is required for the self-renewal and differentiation of mammary progenitors because its abrogation leads to a failure to maintain the mammary epithelial regenerative potential and also results in defects in luminal lineage differentiation.

References

Jan 18, 1994·Proceedings of the National Academy of Sciences of the United States of America·P W HindsR A Weinberg
Aug 30, 2000·Nature·C M PerouD Botstein
Aug 25, 2001·Breast Cancer Research and Treatment·J StinglJ T Emerman
May 21, 2003·Genes & Development·Gabriela DontuMax S Wicha
Jun 12, 2003·Methods : a Companion to Methods in Enzymology·Jayanta DebnathJoan S Brugge
Sep 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tracey M RowlandsPamela Cowin
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yi LiHarold E Varmus
Jan 6, 2006·Nature·John StinglConnie J Eaves
Jan 7, 2006·Nature·Mark ShackletonJane E Visvader
Jan 19, 2006·Breast Cancer Research : BCR·Katherine E SleemanMatthew J Smalley
Dec 26, 2006·Nature Cell Biology·Marie-Liesse Asselin-LabatJane E Visvader
Dec 28, 2006·The Journal of Cell Biology·Katherine E SleemanMatthew J Smalley
Apr 11, 2007·The Journal of Cell Biology·René VilladsenOle W Petersen
Apr 20, 2007·Journal of Cellular Physiology·Brian W BoothGilbert H Smith
Feb 29, 2008·Breast Cancer Research : BCR·Gilbert H Smith, Daniel Medina
Dec 5, 2008·Nature·Elsa QuintanaSean J Morrison

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Citations

Jun 14, 2012·Journal of Cancer Research and Clinical Oncology·Qiao ZhengOfer Reizes
Jul 8, 2011·Nature Reviews. Cancer·Elizabeth A MusgroveRobert L Sutherland
Oct 12, 2010·Cold Spring Harbor Perspectives in Biology·Jane E Visvader, Gilbert H Smith
Oct 9, 2012·Cancer Research·Nelson E BrownPhilip W Hinds
Oct 23, 2010·Breast Cancer Research : BCR·Patrica J KellerCharlotte Kuperwasser
Jun 4, 2011·Breast Cancer Research : BCR·François VaillantJane E Visvader
Aug 27, 2011·Breast Cancer Research : BCR·Kateryna Shostak, Alain Chariot
Jan 6, 2012·Breast Cancer Research : BCR·Ben Tran, Philippe L Bedard
Oct 24, 2012·Breast Cancer Research : BCR·Mona ShehataJohn Stingl
Feb 2, 2013·Breast Cancer Research : BCR·Gerard A TarulliAlexandra M Pietersen
Aug 21, 2013·Breast Cancer Research : BCR·Alice S KaantaBenjamin G Neel
Jun 16, 2011·International Journal of Molecular Sciences·Tao YinChunyou Wang
Jan 9, 2014·Breast Cancer Research : BCR·Ted H-T ChangAlexandra M Pietersen
Jun 17, 2011·Future Oncology·Marco A Velasco-VelázquezRichard G Pestell
Jan 13, 2015·Frontiers in Biology·Qiaoxiang Dong, Lu-Zhe Sun
May 22, 2010·Journal of Biomedicine & Biotechnology·Yvonne MyalAnne A Blanchard
Jan 7, 2014·Expert Opinion on Investigational Drugs·Mathew C CasimiroRichard G Pestell
Oct 18, 2014·Journal of Hematology & Oncology·Qian ChuKongming Wu
Jan 18, 2012·The International Journal of Biochemistry & Cell Biology·Marco A Velasco-VelázquezRichard G Pestell
Nov 16, 2010·The EMBO Journal·Kuppusamy BalamuruganEsta Sterneck
Feb 24, 2015·Oncogene·A Skibinski, C Kuperwasser
May 15, 2015·Molecular Carcinogenesis·Asha SrinivasanAshakumary Lakshmikuttyamma
Jul 21, 2015·Journal of Mammary Gland Biology and Neoplasia·Lisa M Arendt, Charlotte Kuperwasser
Dec 9, 2014·Cell Adhesion & Migration·Sarah Phillips, Charlotte Kuperwasser
Aug 15, 2014·Developmental Cell·Jay S DesgrosellierDavid A Cheresh
Apr 23, 2015·In Vitro Cellular & Developmental Biology. Animal·Jang Pyo ParkBrian W Booth

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