Cyclin dependent kinase activating kinases

Current Opinion in Cell Biology
R A Sclafani

Abstract

The cyclin dependent kinase activating kinase (CAK) has roles in both cell cycle regulation and transcription. CAK assembly is regulated either by additional protein binding or by phosphorylation. A recent comparison of this kinase from two yeast species shows that different proteins perform distinct roles and that the most studied CAK may function mainly in transcription.

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