PMID: 8986790Dec 24, 1996Paper

Cyclin E, a redundant cyclin in breast cancer

Proceedings of the National Academy of Sciences of the United States of America
J Gray-BablinKhandan Keyomarsi

Abstract

Cyclin E is an important regulator of cell cycle progression that together with cyclin-dependent kinase (cdk) 2 is crucial for the G1/S transition during the mammalian cell cycle. Previously, we showed that severe overexpression of cyclin E protein in tumor cells and tissues results in the appearance of lower molecular weight isoforms of cyclin E, which together with cdk2 can form a kinase complex active throughout the cell cycle. In this study, we report that one of the substrates of this constitutively active cyclin E/cdk2 complex is retinoblastoma susceptibility gene product (pRb) in populations of breast cancer cells and tissues that also overexpress p16. In these tumor cells and tissues, we show that the expression of p16 and pRb is not mutually exclusive. Overexpression of p16 in these cells results in sequestering of cdk4 and cdk6, rendering cyclin D1/cdk complexes inactive. However, pRb appears to be phosphorylated throughout the cell cycle following an initial lag, revealing a time course similar to phosphorylation of glutathione S-transferase retinoblastoma by cyclin E immunoprecipitates prepared from these synchronized cells. Hence, cyclin E kinase complexes can function redundantly and replace the loss of cyclin D-d...Continue Reading

References

Mar 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J A DeCaprioD M Livingston
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·I B RunnebaumS Sukumar
Oct 1, 1995·Molecular and Cellular Biology·J Zalvide, J A DeCaprio
Nov 15, 1995·International Journal of Cancer. Journal International Du Cancer·E A MusgroveR L Sutherland
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·R H MedemaR A Weinberg
Mar 29, 1995·International Journal of Cancer. Journal International Du Cancer·L AagaardJ Bartek
Apr 1, 1995·Trends in Genetics : TIG·A Kamb
May 15, 1995·Genes & Development·C J Sherr, J M Roberts
Mar 9, 1995·Nature·D O Morgan
Dec 1, 1994·Current Opinion in Cell Biology·S J Elledge, J W Harper
Dec 1, 1994·Current Opinion in Cell Biology·E W Lam, N B La Thangue
Nov 18, 1994·Cell·C J Sherr
Dec 16, 1994·Science·L H Hartwell, M B Kastan
Apr 1, 1994·Molecular and Cellular Biology·C E DabrowskiP A Schaffer
Dec 3, 1993·Cell·T Hunter
Jan 1, 1993·Molecular and Cellular Biology·J W LudlowJ A DeCarprio
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K Keyomarsi, A B Pardee
Apr 1, 1993·Current Opinion in Cell Biology·K Nasmyth
Apr 1, 1993·Current Opinion in Cell Biology·E A Nigg
Mar 1, 1996·Nature Medicine·Q P DouK Keyomarsi
Feb 8, 1996·International Journal of Cancer. Journal International Du Cancer·M SakaguchiH Matsuda

❮ Previous
Next ❯

Citations

Aug 11, 2000·Prostaglandins & Other Lipid Mediators·E F Mc Clay
Mar 30, 2000·Cancer Letters·K MakiyamaM Hosaka
Nov 5, 2002·Critical Reviews in Oncology/hematology·F Lerebours, R Lidereau
Feb 19, 2002·Journal of the American College of Surgeons·S Eva Singletary
Mar 5, 1999·Breast Cancer Research and Treatment·P S Steeg, Q Zhou
Aug 24, 2001·Breast Cancer Research and Treatment·K Milde-LangoschT Löning
Aug 4, 2011·The Journal of Antibiotics·Hiroshi YamakiNobuo Tanaka
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H. BlegenG. Auer
Nov 15, 2002·The New England Journal of Medicine·Khandan KeyomarsiSarah S Bacus
Mar 23, 2000·The Journal of Experimental Medicine·R HalabanJ Germino
Nov 30, 2000·Nucleic Acids Research·D C Porter, K Keyomarsi
Oct 17, 2003·Genes & Development·Vincenzo D'AngiolellaDomenico Grieco
Apr 8, 1999·Molecular Pathology : MP·P L FernándezA Cardesa
Jan 5, 2012·The Journal of Clinical Investigation·Floriana ForzatiAlfredo Fusco
Aug 29, 2002·In Vitro Cellular & Developmental Biology. Animal·Jeannine BotosDeborah T Kochevar
Sep 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·J M TrowbridgeM J Garabedian
Mar 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tohru YamadaAnanda M Chakrabarty
May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Pierre RudolphReza Parwaresch
Jul 5, 2008·The American Journal of Pathology·Everardo MaciasMarcelo L Rodriguez-Puebla
Jul 4, 2006·Biochemical and Biophysical Research Communications·Meixiang SangAkira Nakagawara
Dec 10, 1999·Experimental Cell Research·E HullemanJ Boonstra
May 1, 2012·Cell Cycle·Floriana ForzatiAlfredo Fusco
Dec 15, 2010·Cell Cycle·Anne CooleyJacqueline S Jeruss
Oct 18, 2000·Molecular Cell Biology Research Communications : MCBRC·B YuS Wadler
Jun 9, 2016·Journal of Molecular Histology·Zhixuan ZhouMing Shen
Aug 25, 2006·International Journal of Cancer. Journal International Du Cancer·Christine DesmedtChristos Sotiriou
Sep 27, 2006·Journal of Cellular Physiology·Michelle Craig BartonKhandan Keyomarsi
Sep 2, 1999·British Journal of Cancer·D NiederacherM W Beckmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.