Cyclin E amplification, over-expression, and relapse-free survival in HER-2-positive primary breast cancer

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Satu LuhtalaJorma J Isola

Abstract

Cyclin E is a well-characterized cell cycle regulator and an amplified oncogene in breast cancer. Over-expression of cyclin E has generally been associated with poor survival. Recent studies have shown an interaction between HER-2 (ERBB2) and cyclin E, but the exact mechanism is unknown. Interestingly, cyclin E over-expression has been associated with trastuzumab resistance. We studied cyclin E over-expression, CCNE1 amplification, and relapse-free survival in HER-2-positive primary breast cancers treated with and without trastuzumab therapy. Formalin-fixed paraffin-embedded tissue samples from 202 HER-2-positive breast carcinomas were studied. Expression levels of cyclin E and proliferation marker Ki-67 were determined using immunohistochemistry. Chromogenic in situ hybridization (CISH) with a gene-specific bacterial artificial chromosome (BAC) probe was used to analyze presence of CCNE1 amplification. Majority of HER-2-positive breast carcinomas exhibited nuclear staining for cyclin E protein. Cyclin E was highly expressed (≥50 % cells) in 37 % of cases. Incidence of CCNE1 amplification (≥6 gene copies/cell or clusters) was 8 %. Cyclin E amplification and over-expression were strongly associated with each other, grade, hormon...Continue Reading

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Citations

Aug 11, 2017·PloS One·Flora ZagouriGeorge Fountzilas
Oct 26, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Satu LuhtalaJorma Isola
May 1, 2019·Scientific Reports·Diane OjoDamu Tang
Sep 29, 2020·Cancer Medicine·Anders BerglundJong Y Park

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