Cyclin H predicts the poor prognosis and promotes the proliferation of ovarian cancer

Cancer Cell International
Chen PengYuquan Zhang

Abstract

Cell cycle dysregulation plays a key role in the pathogenesis of malignant tumors. As a part of the CDK-activating kinase (CAK) trimeric complex, cyclin H is necessary to regulate the cell cycle and proliferation. This investigation aims to characterize the clinical significance and the biological functions of cyclin H in ovarian cancer. Immunohistochemical staining was performed on 60 ovarian cancer cases, and a correlation between cyclin H expression and the clinical characteristics of ovarian cancer was analyzed. The function of cyclin H in ovarian cancer was further explored using HO8910 cells and a subcutaneous xenograft model of nude mice. Cyclin H was slightly expressed in grade 1 ovarian cancer but highly expressed in grade 2 and grade 3 cancerous tissues. The Spearman's rank correlation analysis showed that the expression of cyclin H is positively correlated with the tumor grade, the FIGO stage, histological grade, and the peritoneal metastasis of ovarian cancer and is also positively correlated with the Ki67 and p-CDK2 in ovarian cancer. Additionally, we found that the five-year survival rate was higher in patients expressing low cyclin H than those expressing high cyclin H. Further, knockdown of cyclin H was achieved...Continue Reading

References

Jan 1, 1995·Molecular and Cellular Biology·D DesaiD O Morgan
Jul 26, 2002·Oncogene·Eberhard SchneiderMathias Montenarh
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·F KayaselcukB Demirhan
Nov 3, 2006·Nature Clinical Practice. Oncology·Thomas J Herzog, Bhavana Pothuri
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jan 30, 2013·Pharmacology & Therapeutics·Santiago Diaz-MoralliMarta Cascante
May 2, 2013·Genes & Cancer·Mathew C CasimiroRichard G Pestell
Jun 21, 2014·The British Journal of Oral & Maxillofacial Surgery·Abitha MuraliS Kannan
May 29, 2015·Molecular Pharmacology·Mary E LawBrian K Law
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
May 4, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Pujade-Lauraine, P Combe
Nov 4, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hetal PatelSimak Ali
Oct 17, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Penelope M Webb, Susan J Jordan
Apr 27, 2017·Cancer Biology & Medicine·Brett M ReidThomas A Sellers
Oct 12, 2017·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Myriam KossaïCatherine Genestie
Nov 29, 2017·Future Oncology·Sergey Karakashev, Katherine M Aird
Dec 1, 2017·Journal of Gynecologic Oncology·Xiyi JiangTianhui Chen
Jan 27, 2018·Cancer Biology & Medicine·Jingwen BaiGuojun Zhang
Mar 15, 2019·Seminars in Oncology Nursing·Christine StewartSuzy Lockwood
Sep 4, 2019·Bioorganic & Medicinal Chemistry Letters·Concepción Sánchez-MartínezAlfonso de Dios

❮ Previous
Next ❯

Citations

Jan 7, 2021·Omics : a Journal of Integrative Biology·Medi KoriKazim Yalcin Arga

❮ Previous
Next ❯

Methods Mentioned

BETA
transfection
PCR
xenografts

Software Mentioned

Modfit

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.