Abstract
Cyclin‑dependent kinase 10 (CDK10) has been indicated to be a candidate tumor suppressor in multiple cancer types. However, to the best of the authors' knowledge, its biological and regulatory functions in glioma have not been previously reported. In the present study, it was demonstrated that overexpression of CDK10 inhibited glioma cell proliferation and metastasis. By contrast, knockdown of CDK10 expression promoted these malignant phenotypes. It was additionally indicated that dysregulated CDK10 expression was associated with epithelial‑mesenchymal transition (EMT) and that it regulated the expression of zinc finger protein SNAI1 (Snail). Furthermore, silencing Snail expression rescued EMT phenotypes induced by CDK10 knockdown, suggesting that Snail may be involved in the mechanistic association between CDK10 and EMT. The present study illustrated that downregulation of CDK10 expression activated Snail‑driven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy.
References
Mar 3, 2004·Human Pathology·Hirotoshi TobiokaNorimasa Sawada
Feb 3, 2005·Acta Neuropathologica·Hiroko Ohgaki, Paul Kleihues
May 3, 2005·Annals of Surgical Oncology·Tracey A MartinWen G Jiang
Aug 23, 2006·Oncogene·Z WangA Nusrat
Jan 30, 2007·Cellular and Molecular Life Sciences : CMLS·M NakadaM E Berens
Feb 5, 2008·Cancer Cell·Elizabeth IornsAlan Ashworth
Aug 2, 2008·The New England Journal of Medicine·Patrick Y Wen, Santosh Kesari
Nov 21, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Jaekyung MyungSung-Hye Park
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
May 7, 2010·CA: a Cancer Journal for Clinicians·Erwin G Van MeirJeffrey J Olson
Sep 30, 2010·International Journal of Molecular Medicine·Tracey A MartinWen G Jiang
Jan 3, 2012·Oncology Reports·Jian-Hua YuYun-Fu Cui
Feb 1, 2012·Brain Pathology·Masaya NagaishiHiroko Ohgaki
Feb 7, 2012·Neuro-oncology·Terri S ArmstrongDavid Schiff
Feb 14, 2012·Gene·Xiang-yu ZhongYun-fu Cui
Jan 22, 2013·Cytotechnology·Yanjie YouHaibo Wang
Jun 7, 2013·Cellular Oncology (Dordrecht)·Yanjie YouYonggang Ran
Jan 22, 2015·Oncotarget·Kyung-Hwa LeeKyung-Sub Moon
Feb 25, 2015·Cellular Oncology (Dordrecht)·Yanjie YouYonggang Ran
Jul 25, 2015·Cytotechnology·Canfeng LinYanjie You
Jul 26, 2015·BMC Cancer·Chao-Qun HongYu-Kun Cui
Sep 24, 2015·Cellular Oncology (Dordrecht)·Yanjie YouFenglan Gao
Nov 12, 2015·Biochemical and Biophysical Research Communications·Hengyuan PangJianjiao Wang