Jan 1, 1987

Cyclo (Leu-Gly) + haloperidol: effects on dopamine receptors and conditioned avoidance responding

A J BeanG E Martin


Behavioral effects of cyclo (Leu-Gly) (cLG), administered either acutely or chronically, were assessed in combination with haloperidol in the rat. cLG administered chronically, produced a significant reduction in the increase in apomorphine-induced stereotypy produced by chronic haloperidol infusion. On the other hand, the same dose of cLG which reduced this induction of dopamine receptor supersensitivity due to chronic haloperidol treatment, failed to produce a change in the potency of haloperidol in blocking conditioned avoidance responding in the rat. Furthermore, degeneration-induced supersensitivity of dopamine neurons, produced by unilateral destruction of the nigrostriatal pathway, was not reduced by acute or chronic treatment with cLG as measured by apomorphine-induced rotation. These data suggest that cLG may decrease motor system side effects thought to be caused by chronic antipsychotic administration without affecting the therapeutic efficacy of the antipsychotic agent.

Mentioned in this Paper

Biochemical Pathway
Cyclic Peptides
Avoidance Learning
Abnormal Degeneration
Intravenous Drug Delivery Systems
Assay OF Haloperidol
Substantia Nigra Structure
Rats, Inbred F344

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