Cyclo-oxygenase-2 expression in esophageal adenocarcinoma as a determinant of clinical outcome following esophagectomy

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
M FranceD I Watson

Abstract

The aim of this study was to determine if cyclo-oxygenase-2 (COX-2) expression in adenocarcinoma of the esophagus affects survival outcome in patients undergoing esophagectomy. Ten patients surviving more than 3 years following an esophagectomy for adenocarcinoma of the esophagus were identified from an esophagectomy database maintained by the University of Adelaide Department of Surgery. An additional group of 10 patients, who underwent esophagectomy for adenocarcinoma, but who died within 12 months of surgery due to recurrent disease, were also identified. Pieces of the original formalin fixed carcinoma tissue embedded in paraffin blocks from all of these patients were obtained, and slices of the tumor specimens underwent immunohistochemical staining with COX-2 protein. The extent of staining was then graded by a single 'blinded' pathologist: grade 0, no staining; grade 1 +, limited staining; and grade 2 +, strong staining. Kaplan-Meier survival curves were then constructed and used to determine correlations between survival and COX-2 staining, tumor T-stage, local lymph node metastases, and tumor vascular invasion. Ninety-five percent (19/20) of patients stained positively for COX-2. Patients with grade 2 + staining had a si...Continue Reading

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Citations

Jan 29, 2008·Cancer Metastasis Reviews·K N SyrigosMuhammad Wasif Saif
Jun 4, 2011·Cancer Prevention Research·Patrick Yachimski, Richard M Peek
Apr 11, 2013·Gastroenterology Research and Practice·Romana IlligDaniel Neureiter
Dec 4, 2010·World Journal of Gastroenterology : WJG·Chin-Ann J OngRebecca C Fitzgerald
Sep 21, 2006·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J-F LiuP Drew
Dec 7, 2007·International Journal of Cancer. Journal International Du Cancer·Jun-Feng LiuPaul A Drew
Oct 25, 2006·Alimentary Pharmacology & Therapeutics·S MehtaM Rhodes
Jul 5, 2012·ANZ Journal of Surgery·George C MayneDamian J Hussey
Aug 12, 2009·Current Opinion in Pharmacology·Bharat B Aggarwal, Prashasnika Gehlot
Apr 2, 2017·Artificial Intelligence in Medicine·Zhen LiYixue Li
Aug 11, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kim L WangConstance T Albarracin

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