Cyclo-oxygenase type 2-dependent prostaglandin E2 secretion is involved in retrovirus-induced T-cell dysfunction in mice

The Biochemical Journal
Souad RahmouniMichel Moutschen

Abstract

MAIDS (murine AIDS) is caused by infection with the murine leukaemia retrovirus RadLV-Rs and is characterized by a severe immunodeficiency and T-cell anergy combined with a lymphoproliferative disease affecting both B- and T-cells. Hyperactivation of the cAMP-protein kinase A pathway is involved in the T-cell dysfunction of MAIDS and HIV by inhibiting T-cell activation through the T-cell receptor. In the present study, we show that MAIDS involves a strong and selective up-regulation of cyclo-oxygenase type 2 in the CD11b+ subpopulation of T- and B-cells of the lymph nodes, leading to increased levels of PGE2 (prostaglandin E2). PGE2 activates the cAMP pathway through G-protein-coupled receptors. Treatment with cyclo-oxygenase type 2 inhibitors reduces the level of PGE2 and thereby reverses the T-cell anergy, restores the T-cell immune function and ameliorates the lymphoproliferative disease.

References

Jul 1, 1992·AIDS Research and Human Retroviruses·M A Nokta, R B Pollard
Jun 1, 1992·The Journal of Experimental Medicine·G MuralidharS L Swain
Mar 1, 1991·AIDS·G M Shearer, M Clerici
Jun 1, 1987·The Journal of Experimental Medicine·D E MosierH C Morse
Jan 1, 1996·Journal of Virology·L DoyonP Jolicoeur
Apr 1, 1997·Journal of Virology·P DuprazP Jolicoeur
Jul 10, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·E M AandahlK Taskén
Feb 5, 1999·Clinical and Experimental Immunology·J L PablosJ J Gomez-Reino
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T D WarnerJ R Vane
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·R M BreyerM D Breyer
May 9, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D P HarrisS L Swain
Jun 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S RahmouniM Moutschen
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Einar Martin AandahlDouglas F Nixon

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Citations

Dec 3, 2011·Cancer Prevention Research·Daniel W FitzgeraldAndrew J Dannenberg
Apr 9, 2011·American Journal of Respiratory and Critical Care Medicine·Hong LiDarryl C Zeldin
Apr 12, 2016·Frontiers in Immunology·Verena Katharina RakerKerstin Steinbrink
Jan 1, 2013·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Khanh vinh quốc L Ng, Lan Thi Hoàng Nguyễn
Nov 29, 2013·European Journal of Clinical Investigation·Maneesh SinghMichel Moutschen
Mar 25, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Randi MosendenKjetil Taskén
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Milada MahicEinar M Aandahl
Jul 22, 2006·Biochemical Society Transactions·K Taskén, A J Stokka

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