Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11β-hydroxysteroid dehydrogenases

Journal of Natural Products
James D Simo MpetgaXiao-Jiang Hao

Abstract

Five new triterpenoids, caloncobic acids A and B (1 and 2), caloncobalactones A and B (3 and 4), and glaucalactone (5), along with the known compounds 3β,21β-dihydroxy-30-nor-(D:A)-friedo-olean-20(29)-en-27-oic acid (6) and acetyltrichadenic acid B (7), were isolated from the leaves of Caloncoba glauca. The structures of 1-5 were elucidated using spectroscopic methods. Compounds 1-7 were evaluated for their inhibitory activities against two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD1 and 11β-HSD2). Compounds 1 and 2 exhibited strong inhibitory activities against mouse (EC(50) 132 and 13 nM) and human (EC(50) 105 and 72 nM) 11β-HSD1.

References

Dec 1, 1971·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·J SakakibaraM Yasue
Dec 6, 2005·Chemical & Pharmaceutical Bulletin·Dae Sik JangJin Sook Kim
Feb 5, 2008·Bioorganic & Medicinal Chemistry Letters·Huaiyu YangJianhua Shen
Oct 17, 2008·Journal of Natural Products·Hsi-Lin ChiuYueh-Hsiung Kuo
Jun 8, 2010·Journal of Natural Products·Akihito YokosukaYoshihiro Mimaki

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Citations

Oct 30, 2016·Journal of Natural Products·Xiao-Jing LvShi-Shan Yu
Oct 25, 2014·Natural Product Reports·Robert A Hill, Joseph D Connolly
Mar 13, 2020·The American Journal of Chinese Medicine·Yu ZhangYan-Yan Jiang
May 30, 2014·Organic & Biomolecular Chemistry·Jin-Hai YuJian-Min Yue
Jul 23, 2018·Natural Products and Bioprospecting·Yue-Mao Shen, Duo-Zhi Chen
May 6, 2020·Natural Product Reports·Aldo AlmeidaSøren Bak
Sep 28, 2021·Natural Product Research·Chimène Victoire Tchamadeu KeugwaJean Duplex Wansi

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