Cycloartenol triterpenoid saponins from Cimicifuga simplex (Ranunculaceae) and their biological effects

Chinese Journal of Natural Medicines
Lun WuHaiXue Kuang

Abstract

The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9,19-cyclolanostane triterpenoid glycosides, which are distributed widely in Cimicifuga plants, but not in other members of the Ranunculaceae family, and are considered to be characteristics of the Cimicifuga genus. This type of triterpenoid glycoside possesses several important biological activities. More than 120 cycloartane triterpene glycosides have been isolated from Cimicifuga simplex Wormsk. The aim of this review article is to summarize all the major findings based on the available scientific literatures on C. simplex, with a focus on the identified 9,19-cyclolanostane triterpenoid glycosides. Biological studies of cycloartane triterpene glycosides from Cimicifuga spp. are also discussed.

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Citations

Jun 17, 2016·Immunopharmacology and Immunotoxicology·Ji-Yoon ChoiMi-Sook Dong
Jun 8, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zúlima Jannette Gutiérrez NavaEnrique Jiménez-Ferrer
Feb 15, 2020·Natural Product Reports·Robert A Hill, Joseph D Connolly

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