Aug 7, 2014

Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management

Neuro-Signals
Fanny C F IpNancy Y Ip

Abstract

Cycloastragenol (CAG) is an aglycone of astragaloside IV. It was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. The present study demonstrates that CAG stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, CAG promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro. The distinct telomerase-activating property of CAG prompted evaluation of its potential application in the treatment of neurological disorders. Accordingly, CAG induced telomerase activity and cAMP response element binding (CREB) activation in PC12 cells and primary neurons. Blockade of CREB expression in neuronal cells by RNA interference reduced basal telomerase activity, and CAG was no longer efficacious in increasing telomerase activity. CAG treatment not only induced the expression of bcl2, a CREB-regulated gene, but also the expression of telomerase reverse transcriptase in primary cortical neurons. Interestingly, oral administration of CAG for 7 days attenuated depression-like behavior in experimental mice. In conclusion, CAG stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and indu...Continue Reading

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Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Ischemia
CAMP Response Element Binding
Cyclic AMP-Responsive DNA-Binding Protein
T-Lymphocyte
Exertion
Cortex Bone Disorders
Tissue Membrane
Dimethyl Sulfoxide
Astragalus membranaceus

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