Cyclodextrin-Based Macromolecular Systems as Cholesterol-Mopping Therapeutic Agents in Niemann-Pick Disease Type C

Macromolecular Rapid Communications
Antonino Puglisi, Yusuf Yagci

Abstract

Over the last decade, cyclodextrins (CDs) have gained considerable attention as a potential therapeutic intervention in the treatment of the rare genetic condition Niemann-Pick type C disease (NPC). However, the oligosaccharide in its monomeric form suffers from serious side effects, especially from a pharmacokinetic and biodistribution standpoint. CD-based macromolecular systems hold great promise to overcome such limitations and might provide an improved therapeutic approach in reducing cholesterol accumulation in NPC. In the present article, the latest developments and synthetic strategies in the preparation of CD-containing polymers as cholesterol-mopping therapeutic agents in NPC are summarized.

References

Jan 1, 1987·Chemical & Pharmaceutical Bulletin·J SzemanT Nagai
Oct 1, 1996·Journal of Pharmaceutical Sciences·T Loftsson, M E Brewster
Nov 1, 1996·Journal of Pharmaceutical Sciences·R A Rajewski, V J Stella
Feb 1, 1997·Journal of Pharmaceutical Sciences·T Irie, K Uekama
May 1, 1997·Pharmaceutical Research·V J Stella, R A Rajewski
Jun 6, 2000·Advanced Drug Delivery Reviews·V J StellaV Zia
Jun 6, 2000·Advanced Drug Delivery Reviews·L Szente, J Szejtli
Jan 5, 2002·Advanced Drug Delivery Reviews·Serguei V VinogradovAlexander V Kabanov
Jan 15, 2002·Life Sciences·F CamargoJ Blanchard
Feb 19, 2002·Chemical Reviews·József Szejtli
Feb 19, 2002·Chemical Reviews·Kaneto UekamaTetsumi Irie
Aug 12, 2004·Chemical & Pharmaceutical Bulletin·Kaneto Uekama
Dec 2, 2004·Nature Reviews. Drug Discovery·Mark E Davis, Marcus E Brewster
Jul 16, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sarah Gould, Robert C Scott
Nov 22, 2005·Expert Opinion on Drug Delivery·Thorsteinn LoftssonTomi Järvinen
Nov 24, 2005·International Journal of Pharmaceutics·Donald E Owens, Nicholas A Peppas
Dec 16, 2005·AAPS PharmSciTech·Rajeswari ChallaR K Khar
Mar 9, 2006·Chemical Reviews·Gerhard WenzAxel Müller
Mar 23, 2006·Journal of the American Chemical Society·Tooru OoyaHideyoshi Harashima
Dec 2, 2006·International Journal of Pharmaceutics·Thorsteinn Loftsson, Dominique Duchêne
Jun 5, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Julie A ChampionSamir Mitragotri
Jul 3, 2007·Advanced Drug Delivery Reviews·Marcus E Brewster, Thorsteinn Loftsson
Sep 11, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Krzysztof Cal, Katarzyna Centkowska
Sep 25, 2007·Nature Biotechnology·Hak Soo ChoiJohn V Frangioni
Dec 14, 2007·Journal of Lipid Research·Benny LiuJohn M Dietschy
Aug 5, 2008·Molecular Pharmaceutics·Frank AlexisOmid C Farokhzad
Oct 2, 2008·Nature Reviews. Drug Discovery·Aleksey G Kazantsev, Leslie M Thompson
Jan 28, 2009·Proceedings of the National Academy of Sciences of the United States of America·Benny LiuJohn M Dietschy
Aug 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Keiichi MotoyamaHidetoshi Arima
Dec 22, 2009·Chemical Society Reviews·Lei FangJ Fraser Stoddart
Mar 27, 2010·The Lancet Oncology·Hisataka KobayashiSatomi Kawamoto
Mar 18, 2011·Current Opinion in Lipidology·Jean E Vance, Kyle B Peake
Jul 10, 2012·Chemical Society Reviews·Alyssa-Jennifer AvestroJ Fraser Stoddart
Dec 5, 2012·The Journal of Experimental Medicine·Jiaqi YaoM Flint Beal
Aug 1, 2013·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Resmi AnandSandra Monti
Dec 21, 2013·Current Topics in Medicinal Chemistry·Luis García-RíoJosé Blanco-Méndez

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Citations

Oct 3, 2020·Pharmaceuticals·Adrián MatencioFrancesco Trotta
May 16, 2021·International Journal of Pharmaceutics·Blanca Lorenzo-VeigaHakon Hrafn Sigurdsson
Jun 3, 2021·Polymers·Adrián MatencioFrancesco Trotta
Sep 26, 2019·Biomacromolecules·Antonino PuglisiYusuf Yagci
Dec 7, 2021·Frontiers in Chemistry·Antonino PuglisiErik Reimhult

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