Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam

Pharmaceutical Development and Technology
Wipada SamprasitPraneet Opanasopit

Abstract

This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems [dimethylformamide (DMF) and ethyl alcohol (EtOH)] was performed. Prepared films were evaluated for morphology, physical, and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers. The results showed that MX/HPβCD complexes improved the solubility of MX. PVP also increased MX solubility and the stability of MX/HPβCD complexes. Films were successfully prepared by two solvent systems with fiber in the nanometer range. MX was well incorporated into the films (100% efficiency). The X-ray patterns and DSC experiment indicated an amorphous form of MX. A fast disintegration time and burst release of MX was obtained from EtOH system. Cytotoxicity testing of the films produced by EtOH system proved safer than the DMF system. In vivo studies revealed that films rapidly dissolved in the mouth and had a less bitter taste than MX. These results suggest that electospun films from EtOH ...Continue Reading

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Jun 11, 2014·Pharmaceutical Development and Technology·Wipada SamprasitPraneet Opanasopit
Apr 23, 2015·International Journal of Pharmaceutics·Wipada SamprasitPraneet Opanasopit

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Citations

Sep 26, 2020·Expert Opinion on Drug Delivery·Yidi MaHongzhuo Liu
Nov 24, 2020·International Journal of Nanomedicine·Alaa Yaser DarweshMahasen Mohamed Meshali
Mar 7, 2021·Biomolecules·Gustavo Marinho MirandaJaime Ribeiro-Filho
Mar 19, 2020·Molecular Pharmaceutics·Pan LiDing-Kun Zhang

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