Cyclodextrin containing biodegradable particles: from preparation to drug delivery applications

International Journal of Pharmaceutics
Nadiah ZafarAbdelhamid Elaissari

Abstract

Cyclodextrins (CDs) offer a very broad spectrum of applications in diverse fields of drug delivery. They are a family of cyclic α-(1-4)-linked oligosaccharides of α-d-glucopyranose subunits forming a more hydrophobic central cavity and a hydrophilic outer shell. CDs bear cage like supramolecular structures, similar to calixarenes, cyclophanes and crown ethers. No covalent bonds are required to host a guest molecule in the central cavity. The aim of this review is to throw light on some of the applications and formulation techniques for the novel multifunctional CD based nanocarriers used in diverse areas of drug delivery. Furthermore, this article highlights the molecular structure, chemical, complexation properties and the use of CDs in nanosystems like liposomes, magnetic nanoparticles, biodegradable polymers, micro and nanospheres and capsules.

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Citations

Nov 3, 2015·International Journal of Pharmaceutics·Muhammad IqbalAbdelhamid Elaissari
Sep 24, 2015·Environmental Science and Pollution Research International·Zied MarzouguiAbdelhamid Elaissari
Jun 11, 2014·International Journal of Pharmaceutics·Nadiah ZafarAbdelhamid Elaissari
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Nov 10, 2016·International Journal of Pharmaceutics·Waisudin BadriAbdelhamid Elaissari
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Dec 11, 2020·Analytical Methods : Advancing Methods and Applications·Auraya ManaprasertsakThitinun Karpkird
Dec 7, 2018·Chemistry and Physics of Lipids·Sandra Cruz Dos SantosVânia Rodrigues de Lima
Apr 6, 2021·European Journal of Pharmacology·Eric Aian P SilvaAndré S Barreto
Dec 7, 2019·Journal of Medicinal Chemistry·Irene M Mavridis, Konstantina Yannakopoulou
Oct 20, 2020·ACS Omega·Avilasha A SandilyaM Hamsa Priya

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