Cyclodextrin controlled release of poorly water-soluble drugs from hydrogels

Drug Delivery
Henriette Sie WoldumFlemming Madsen

Abstract

The effect of 2-hydroxypropyl-beta-cyclodextrin and gamma-cyclodextrin on the release of ibuprofen, ketoprofen and prednisolone was studied. Stability constants calculated for inclusion complexes show size dependence for complexes with both cyclodextrins. Hydrogels were prepared by ultraviolet irradiation and release of each model drug was studied. For drugs formulated using cyclodextrins an increase in the achievable concentration and in the release from hydrogels was obtained due to increased solubility, although the solubility of all gamma-cyclodextrin complexes was limited. The load also was increased by adjusting pH for the acidic drugs and this exceeds the increase obtained with gamma-cyclodextrin addition.

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Citations

Sep 29, 2011·AAPS PharmSciTech·Paulo José SalústioHelena M Cabral Marques
Jul 27, 2012·Therapeutic Delivery·Monica VialpandoGuy Van den Mooter
Dec 17, 2011·Micron : the International Research and Review Journal for Microscopy·Goutam ThakurDebdoot Sheet
Jun 1, 2011·Biotechnology Progress·Pravin R Ninawe, Satish J Parulekar
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Esmat JalalvandiStephen C Moratti
Aug 11, 2016·Scientific Reports·Chaitanya Kumar ThotaVirander Singh Chauhan
Jul 20, 2011·Journal of Polymer Science. Part B, Polymer Physics·Bret D UleryCato T Laurencin
Aug 28, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Rabia Mateen, Todd Hoare
Jul 1, 2021·Journal of Biomedical Materials Research. Part a·Line Aanerud OmtvedtDaria Sergeevna Zaytseva-Zotova

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