Cyclodextrin-poloxamer aggregates as nanocarriers in eye drop formulations: dexamethasone and amphotericin B

Drug Development and Industrial Pharmacy
Phatsawee JansookThorsteinn Loftsson

Abstract

In this present study cyclodextrin (CD)-poloxamer aggregates were characterized and developed as ophthalmic drug carriers. The combined effect of γCD/2-hydroxypropyl-γCD (HPγCD) mixtures and poloxamer on solubilization and permeability of two model drugs, dexamethasone (Dex) and amphotericin B (AmB), was investigated. The CD-poloxamer interaction and complex aggregation were examined by (1)H nuclear magnetic resonance ((1)H-NMR), their solubilizing ability by high-performance liquid chromatography, and their particle size determined by dynamic light scattering and transmission electron microscopy. Formulations containing either 1.5% w/v Dex or 0.15% w/v AmB in eye drop suspensions containing various γCD/HPγCD ratios and poloxamer 407 (P407) were prepared. The solubility of the drugs, surface tension and hemolytic effect of the eye drops and drug permeation from selected formulations were determined. The (1)H-NMR study showed that P407 formed inclusion complex with CDs by inserting its poly(propylene oxide) segment into the CD cavity. P407 and γCD interacted with each other to form nanosized aggregates, and the observed concentration of dissolved γCD and P407 progressively decreased with increasing γCD and P407 concentrations. I...Continue Reading

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Citations

Sep 7, 2018·Drug Development Research·Shery Jacob, Anroop B Nair
Jan 16, 2019·Materials·Blanca Lorenzo-VeigaThorsteinn Loftsson
Sep 26, 2020·International Journal of Molecular Sciences·Ruslan KashapovOleg Sinyashin
Feb 23, 2021·Royal Society Open Science·Thomas SwiftStephen Rimmer
Jun 17, 2020·Current Drug Targets·Malwina LachowiczMichał Kołodziejczyk
May 16, 2021·International Journal of Pharmaceutics·Blanca Lorenzo-VeigaHakon Hrafn Sigurdsson
Aug 11, 2021·Pharmaceutics·Virginia AiassaAriana Zoppi

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