PMID: 489015Sep 1, 1979Paper

Cycloheximide-resistance in Chinese hamster ovary cells and human fibroblast cells. Cytogenetic and biochemical characterization

Human Genetics
H PöcheS Zakrzewski

Abstract

Cycloheximide(CHM)-resistant mutant Chinese hamster ovary (CHO) and human cells were induced with N-nitrosomethylurea (NMU) and ethyl methanesulfonate (EMS); the mutants were viable and showed unlimited growth in the presence of CHM (7 X 10(-7) M), whereas this concentration inhibits protein synthesis in vivo as well as in vitro. No numerical or structural chromosomal aberrations were found in the mutant cells. In vitro analysis shows that the ribosomes confer resistance against cycloheximide.

References

Jul 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C A SuttonR L Hallberg
Jan 1, 1979·Methods in Enzymology·K H Nierhaus, F Dohme
Oct 1, 1977·Genetics·L K Bleyman, P J Bruns
Jan 12, 1972·Nature: New Biology·H C Wang, S Fedoroff
Aug 28, 1973·Molecular & General Genetics : MGG·M Pongratz, W Klingmüller
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Jan 1, 1972·Molecular & General Genetics : MGG·F B HaugliA Jimenez
Oct 1, 1971·Journal of Cellular Physiology·M Harris

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