PMID: 6164021Feb 6, 1981Paper

Cycloleucine-induced vacuolation of myelin is associated with inhibition of protein methylation

Neuroscience Letters
D H SmallR M Anderson

Abstract

Chickens injected with cycloleucine developed vacuolation of myelin similar to that seen in humans with vitamin B12 deficiency. Cycloleucine, an inhibitor of the formation of S-adenosylmethionine, decreased the incorporation of methyl groups into methylarginine in myelin basic protein in vivo. The need for methylcobalamin for the conversion of homocysteine to methionine and the requirement that myelin basic protein may be methylated, offer a rational explanation for the myelin lesions observed in cases of vitamin B12 deficiency where there is increasing evidence that methyl-, rather than adenosylcobalamin is required to prevent dysmyelination.

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Citations

Jan 1, 1993·Journal of Inherited Metabolic Disease·R Surtees
Jan 1, 1988·Molecular Neurobiology·A T Campagnoni, W B Macklin
Nov 7, 1986·Biochimica Et Biophysica Acta·G H ParkS Kim
May 1, 1997·The International Journal of Biochemistry & Cell Biology·S KimW K Paik
Mar 6, 2012·The Quarterly Review of Biology·Angelique P Corthals
Sep 17, 1984·Biochemical and Biophysical Research Communications·S KimW K Paik
Sep 1, 1995·Baillière's Clinical Haematology·D G Weir, J M Scott
Jul 1, 1988·Journal of Neurochemistry·A T Campagnoni
Jan 1, 1982·Journal of Neurochemistry·D H Small, P R Carnegie
Jun 30, 1987·Biochemical and Biophysical Research Communications·P R YoungC M Waickus
Jan 1, 1986·Journal of Neuroscience Research·S KimW K Paik

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