Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer

Cancer Research
Takiko DaikokuSudhansu K Dey

Abstract

Cyclooxygenases-1 and -2 (Cox-1 and Cox-2) are two distinct isoforms that catalyze the conversion of arachidonic acid to prostaglandins. The role of Cox-2 in a variety of cancers is well recognized, but the contribution of Cox-1 remains much less explored. We have previously shown that human epithelial ovarian tumors have increased levels of Cox-1, but not Cox-2. We also observed that Cox-1 is highly expressed in a mouse model of epithelial ovarian cancer (EOC), which lacks p53 but overexpresses c-myc and K-ras or c-myc and Akt. More importantly, a Cox-1-selective inhibitor, SC-560, attenuates EOC growth. In the present investigation, we used various genetically engineered mouse models of EOC to determine whether Cox-1 overexpression is unique to specific genetic and oncogenic alterations or is widespread. These models include: (a) deletion of both p53 and Rb, (b) induction of the transforming region of SV40 under the control of Mullerian inhibitory substance type II receptor, or (c) activation of K-Ras in the absence of Pten locally in the ovarian surface epithelium. We found that these three models, which produce spontaneous EOC, also show up-regulated expression of Cox-1, but not Cox-2. The results provide further evidence t...Continue Reading

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Citations

Jan 30, 2008·Applied Immunohistochemistry & Molecular Morphology : AIMM·Brian J PhilipsUddhav P Kelavkar
Nov 19, 2008·Journal of Ovarian Research·Siva Kumar PanguluriSham S Kakar
Feb 23, 2011·International Journal of Molecular Sciences·Wei LiLing-Yun Zhai
Mar 25, 2010·World Journal of Gastroenterology : WJG·Paloma Martín-SanzLisardo Boscá
May 17, 2014·European Journal of Medicinal Chemistry·Maria Grazia PerroneAntonio Scilimati
Jul 3, 2007·Neoplasia : an International Journal for Oncology Research·Xinlei ChenM Ram Sairam
Jan 24, 2012·Journal of Medicinal Chemistry·Andy J LiedtkeLawrence J Marnett
Jan 5, 2008·European Journal of Clinical Investigation·B M ErovicD Thurnher
Jul 22, 2009·International Journal of Cancer. Journal International Du Cancer·Shahab UddinAdnan Munkarah
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Li-Xia HuYue-Yin Pan
Jul 25, 2014·The American Journal of Pathology·Takiko DaikokuSudhansu K Dey
Dec 31, 2011·American Journal of Obstetrics and Gynecology·Gustavo C RodriguezCatherine P Barry
Feb 26, 2013·Cancer Treatment Reviews·Francesca RicciGiovanna Damia
Jan 12, 2013·Brain, Behavior, and Immunity·Johan RuudAnders Blomqvist
Feb 11, 2015·Cancer Epidemiology·Christina M NagleUNKNOWN Australian Ovarian Cancer Study Group
Nov 30, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jia XiaoGeorge L Tipoe
Oct 25, 2014·International Journal of Molecular Sciences·Wei LiJane Wang
May 5, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Xiangyang Zeng, Shuijing Yi
Sep 19, 2019·Scientific Reports·Jiang YangMarsha A Moses
Jan 29, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xiaofei SunSudhansu K Dey
Sep 29, 2020·Frontiers in Pharmacology·Paige G SmithJocelyn C Reader
Oct 21, 2010·Journal of Ovarian Research·Bridget A QuinnDenise C Connolly

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