Cyclooxygenase-2 as a signaling molecule in radiation-induced bystander effect

Molecular Carcinogenesis
Tom K Hei

Abstract

Radiation-induced bystander effect represents a paradigm shift in our understanding of the radiobiological effects of ionizing radiation in that extranuclear and extracellular effects may also contribute to the final biological consequences of exposure to low doses of radiation. Evidence suggests that targeted cytoplasmic irradiation results in mutation in the nucleus of the "hit" cells and that cells, which are not directly hit by an alpha particle, whether nuclear or cytoplasm, but are in the vicinity of one that does get hit, contribute to the genotoxic response of the cell population. Although radiation-induced bystander effects have been well documented in a variety of biological systems, the mechanism is not known. Using the Columbia University charged particle beam in conjunction with a novel strip dish design, we showed recently that the cyclooxygenase-2 (COX-2) signaling cascade plays an essential role in the bystander process. Treatment of bystander cells with NS-398, which suppresses COX-2 activity, significantly reduced the bystander effect as well as the induction of the mitogen-activated protein kinase (MAPK) pathways. These results provided the first evidence that the COX-2-related pathway, which is essential in ...Continue Reading

References

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Citations

Aug 5, 2009·Carcinogenesis·Jennifer S DickeyWilliam M Bonner
Sep 4, 2012·Nucleic Acids Research·Jennifer S DickeyOlga A Martin
Sep 22, 2010·International Journal of Radiation Biology·Sharon NugentJames E J Murphy
Oct 22, 2013·Cancer Letters·Hongzhi WangWei Han
Dec 18, 2013·Cancer Letters·Vasiliki I HatziAlexandros G Georgakilas
Dec 9, 2014·RNA Biology·Shuai XuJufang Wang
Aug 6, 2015·Radiation Protection Dosimetry·Yoshitaka MatsumotoYoshiya Furusawa
May 12, 2011·International Journal of Radiation Biology·Fanghua LiZengliang Yu
May 17, 2012·International Journal of Radiation Biology·Fernando P FariaCarlos H C Moreira
Sep 24, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Susanne Burdak-RothkammKevin M Prise
Aug 22, 2007·The International Journal of Biochemistry & Cell Biology·Rajamanickam BaskarM Prakash Hande
Jan 25, 2008·Critical Care Medicine·Mark CoburnNicholas P Franks
Jan 10, 2008·Physics in Medicine and Biology·M D GowC E Mothersill
Mar 3, 2009·The Oncologist·Philippe F SimardNancy J Tarbell
Mar 1, 2007·Journal of Radiation Research·Nobuyuki HamadaYasuhiko Kobayashi

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