Cyclooxygenase-2 (Cox-2) expression and angiogenesis in glioblastoma

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Onder OnguruOmer Gunhan

Abstract

Cyclooxygenase-2 (Cox-2), the key enzyme that catalyzes the first steps in the biosynthesis of the prostaglandins from arachidonic acid, appears to play a role in the regulation of progression, invasiveness and angiogenesis of various neoplasms. We analyzed the immunohistochemical expression of Cox-2 and angiogenic parameters (microvessel density (MVD) and vascular patterns) in 54 glioblastomas. We also examined their relation with prognosis. Cox-2 immunohistochemical expression was observed in 48 tumors (89%). There was no staining in six tumors (11%). On univariate analysis, MVD was correlated with a poor outcome (MVD > 70; hazard ratio, 0.441; 95% confidence interval, 0.200-0.975, P = 0.041). But MVD showed no prognostic impact on multivariate analysis. Neither Cox-2 expression nor vascular pattern showed prognostic value. The difference in Cox-2 expression between the classical and bizarre vascular pattern in glioblastomas was statistically significant (P = 0.047). However, no correlation was found between Cox-2 expression and MVD. These findings suggest that Cox-2 is heterogeneously expressed in glioblastomas without a significant association with MVD. However, Cox-2 expression may be related to vascular pattern in gliobla...Continue Reading

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Citations

Jul 28, 2009·Cardiovascular Research·Nico P Dantuma, Kristina Lindsten
Nov 21, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Jaekyung MyungSung-Hye Park
Oct 22, 2008·Expert Review of Neurotherapeutics·Sajani S Lakka, Jasti S Rao
Apr 13, 2010·Clinical Biochemistry·Rafael De ArmasYves Denizot
Oct 19, 2016·Drug Discovery Today·Jiange QiuJianxiong Jiang
Nov 10, 2013·Cancers·Brian J AhnHideho Okada
May 22, 2020·Cancer Cell International·Paola PalumboBenedetta Cinque

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