Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors

The Journal of Clinical Endocrinology and Metabolism
K J SalesH N Jabbour

Abstract

The prevalence of cervical cancer in South African women is reported as being the highest in the world, occurring, on the average, in 60 of every 100,000 women. Cervical cancer is thus considered an important clinical problem in sub-Saharan AFRICA: Recent studies have suggested that epithelial tumors may be regulated by cyclooxygenase (COX) enzyme products. The purpose of this study was to determine whether cyclooxygenase-2 (COX-2) expression and PGE(2) synthesis are up-regulated in cervical cancers. Real-time quantitative RT-PCR and Western blot analysis confirmed COX-2 ribonucleic acid and protein expression in all cases of squamous cell carcinoma (n = 8) and adenocarcinoma (n = 2) investigated. In contrast, minimal expression of COX-2 was detected in histologically normal cervix (n = 5). Immunohistochemical analyses localized COX-2 expression and PGE(2) synthesis to neoplastic epithelial cells of all squamous cell (n = 10) and adenocarcinomas (n = 10) studied. Immunoreactive COX-2 and PGE(2) were also colocalized to endothelial cells lining the microvasculature. Minimal COX-2 and PGE(2) immunoreactivity were detected in normal cervix (n = 5). To establish whether PGE(2) has an autocrine/paracrine effect in cervical carcinoma...Continue Reading

References

Jan 1, 1978·Journal of Reproduction and Fertility·A A TempletonR W Kelly
Nov 11, 1992·International Journal of Cancer. Journal International Du Cancer·N MuñozN Ascunce
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·T Hla, K Neilson
May 8, 1991·Biochimica Et Biophysica Acta·D L DeWitt
Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R W KellyM J O'Sullivan
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T AareleidM Hakama
Jan 5, 1996·Biochimica Et Biophysica Acta·H R Herschman
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TsujiiR N DuBois
May 1, 1997·The Journal of Clinical Investigation·H ShengR N DuBois
Jan 19, 1999·Cancer Research·K C ZimmermannK Schrör
Apr 10, 1999·The Journal of Biological Chemistry·K SubbaramaiahA J Dannenberg
Apr 17, 1999·The Journal of Biological Chemistry·T G BrockM Peters-Golden

❮ Previous
Next ❯

Citations

Dec 3, 2011·Cancer Prevention Research·Daniel W FitzgeraldAndrew J Dannenberg
Nov 13, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Kurt J Sales, Henry N Jabbour
Sep 11, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yunguang LiYanli Li
Jul 21, 2010·Biochemical Pharmacology·Mi-Kyung KimYong-Sang Song
Sep 28, 2005·The Journal of Investigative Dermatology·Juliette Lois LeeMohammad Athar
Dec 16, 2005·The Journal of Investigative Dermatology·Cristina Rodriguez-BurfordAlice P Pentland
Sep 16, 2006·The Journal of Investigative Dermatology·Sabine BrouxhonAlice P Pentland
Nov 5, 2003·Clinical Lung Cancer·Santiago Ballaz, James L Mulshine
Jan 18, 2006·Free Radical Biology & Medicine·Ingeborg HeirmanJohan Grooten
Jun 30, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·I GutowskaD Chlubek
Mar 26, 2013·Pharmacology & Therapeutics·Viktoria KonyaAkos Heinemann
Jan 23, 2010·BMC Cell Biology·Margaret C KeightleyKurt J Sales
Feb 20, 2004·Respiratory Medicine·D K PetkovaA J Knox
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jieqi KeXiaoping Wan
Jul 6, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jun LiHoward P Glauert
Oct 30, 2007·Toxicology and Applied Pharmacology·Job C TharappelHoward P Glauert
Aug 6, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Rupal DevaSantosh Nigam
Apr 10, 2004·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Rajani Ravi, Atul Bedi
Aug 12, 2014·Molecular Human Reproduction·Kurt J SalesArieh A Katz
Jul 30, 2017·International Journal of Molecular Sciences·Helene HeideggerBernd Kost
May 29, 2003·British Journal of Cancer·H T SørensenJ A Baron
Jan 22, 2004·British Journal of Cancer·G P BolandN J Bundred
Apr 13, 2006·Virchows Archiv : an International Journal of Pathology·Yasuyoshi MiyataHiroshi Kanetake

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.