PMID: 25743830Mar 7, 2015Paper

Cyclooxygenase-2 expression in invasive breast carcinomas of no special type and correlation with pathological profiles suggest a role in tumorigenesis rather than cancer progression

Asian Pacific Journal of Cancer Prevention : APJCP
Nurul Akmar MisronNik Raihan Nik Mustapha

Abstract

COX-2 has been shown to play an important role in the development of breast cancer and increased expression has been mooted as a poor prognostic factor. The purpose of this study was to investigate the relationship between COX-2 immunohistochemical expression and known predictive and prognostic factors in breast cancer in a routine diagnostic histopathology setting. Formalin-fixed paraffin- embedded tumour tissue of 144 no special type (NST) invasive breast carcinomas histologically diagnosed between January 2009 and December 2012 in Hospital Sultanah Bahiyah, Alor Setar, Kedah were immunostained with COX-2 antibody. COX-2 overexpression was analysed against demographic data, hormone receptor status, HER2- neu overexpression, histological grade, tumour size and lymph node status. COX-2 was overexpressed in 108/144 (75%) tumours and was significantly more prevalent (87%) in hormone receptor-positive tumours. There was no correlation between COX-2 overexpression and HER2/neu status. Triple negative cancers had the lowest prevalence (46%) (p<0.05). A rising trend of COX-2 overexpression with increasing age was observed. There was a significant inverse relationship with tumour grade (p<0.05), prevalences being 94%, 83% and 66% in g...Continue Reading

References

Sep 8, 2000·BMJ : British Medical Journal·K McPhersonJ M Dixon
Feb 19, 2002·The Journal of Steroid Biochemistry and Molecular Biology·A M BrodieJ H Thijssen
Mar 20, 2002·Cancer Causes & Control : CCC·Robert E Tarone, Kenneth C Chu
Jul 29, 2003·Journal of Cancer Research and Clinical Oncology·Pia WülfingLudwig Kiesel
Sep 20, 2005·The Breast : Official Journal of the European Society of Mastology·M H ChoK W Min
Jun 27, 2006·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K ParkJ-Y Kim
Aug 22, 2006·International Journal of Cancer. Journal International Du Cancer·G FürstenbergerA J R Habenicht
Jun 22, 2007·International Journal of Cancer. Journal International Du Cancer·Emanuela de MoraesPierre Hainaut
Jun 1, 2005·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Eunmi NamSun Hee Sung
Feb 18, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michelle D HolmesSusan E Hankinson
May 14, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stuart J Schnitt
Jun 12, 2010·Expert Opinion on Therapeutic Targets·Antonella MigliettaClaudia Bocca
Mar 5, 2011·Pathology, Research and Practice·Ibrahim Metin ÇirişFatma Nilgün Kapucuoğlu
Feb 12, 2014·American Journal of Clinical Pathology·Sarah J R DeanAnthony Rhodes
Mar 7, 2014·International Journal of Cancer. Journal International Du Cancer·Andrea MarkkulaHelena Jernström
Jul 8, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Manal Ali ShalabyHesham Mahmoud Saeed
Aug 13, 2014·World Journal of Clinical Oncology·Ozlem Yersal, Sabri Barutca

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Citations

Feb 9, 2016·Seminars in Cancer Biology·Nagendra Sastry YarlaGovinda Rao Duddukuri
Oct 27, 2017·Nutrition and Cancer·Katarzyna Owczarek, Urszula Lewandowska
Apr 30, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Zhen-Qin Qiu, Zhen-Rong Qiu
Nov 12, 2015·World Journal of Gastroenterology : WJG·Marco RagusaMichele Purrello

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