Cyclooxygenase-2 Expression in Non-Small Cell Lung Cancer Correlates With Hypertrophic Osteoarthropathy

The Annals of Thoracic Surgery
Ioannis RotasJean Y Perentes

Abstract

Hypertrophic osteoarthrpathy (HO) is a rare paraneoplasic syndrome associated with non-small cell lung cancer (NSCLC). The pathophysiology of HO is unknown but was recently related to enhanced levels of urine prostaglandin E2 (PGE2). Here, we report the case of a patient that presented HO in association with a resectable left upper lobe NSCLC. Following surgery and adjuvant chemotherapy, HO resolved and did not recur with development of a brain metastasis 1 year later. Interestingly, tumor cyclooxygenase-2, an enzyme responsible the synthesis of PGE2, was expressed in the primary tumor but not in the resected metastasis.

References

Aug 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kenneth J O'ByrneMalcolm Ranson
Apr 28, 2011·Cancer·Mary-Clare CathcartKenneth J O'Byrne
Oct 26, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kevin R KozakTorunn I Yock

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Citations

May 16, 2018·BMC Musculoskeletal Disorders·Francesco BozzaoFabio Fischetti

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