Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
K M SheehanF E Murray

Abstract

Both the expressions of the inducible form of cyclooxygenase-2 and the presence of bone marrow micrometastases are poor prognostic markers in patients with colorectal carcinoma. As cyclooxygenase-2 expression in these tumours is associated with increased metastatic potential in vitro, our objectives were to determine the relationship between cyclooxygenase-2 and haematogenous spread to bone marrow. Thirty-two patients with resection of colorectal carcinoma were evaluated (median age: 69.5 years). Bone marrow was obtained from all patients from both iliac crests before manipulation of the primary tumour. The tumours were of varying stages at diagnosis (5 Dukes' A, 14 Dukes' B, 11 Dukes' C and 2 Dukes' D). Tumour sections were stained for cyclooxygenase-2 using the avidin-biotin immunohistochemical technique. Extent of staining was graded depending on the percentage of epithelial cells staining positive for cyclooxygenase-2. Micrometastases were detected by staining contaminant cytokeratin-18 positive cells in the bone marrow aspirates by either immunohistochemical (ARAAP) or immunological (flow cytometry) methods. Fisher's exact probability test was used to calculate statistical significance. Cyclooxygenase-2 expression in the p...Continue Reading

References

Oct 30, 1981·Biochemical and Biophysical Research Communications·K V Honn, J Meyer
May 6, 1993·The New England Journal of Medicine·F M GiardielloG J Offerhaus
Apr 1, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TsujiiR N DuBois
Sep 18, 1997·The Journal of Clinical Investigation·C S WilliamsR N DuBois
Jun 30, 2000·The New England Journal of Medicine·G SteinbachG Kelloff
Feb 6, 2002·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·S Fiorucci, E Antonelli
Oct 22, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·B BuecherH M Blottière

❮ Previous
Next ❯

Citations

Sep 1, 2005·Journal of Zhejiang University. Science. B·Pan-Qing MengShu Zheng
Oct 7, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Heike Allgayer, Julio A Aguirre-Ghiso
Aug 21, 2008·International Journal of Cancer. Journal International Du Cancer·Sabine RiethdorfKlaus Pantel
Feb 3, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·D F AltomareUNKNOWN Colorectal Micrometastases Study Group
Dec 17, 2005·Current Opinion in Oncology·Otto Zach, Dieter Lutz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
S TórtolaM A Reymond
Journal of B.U.ON. : Official Journal of the Balkan Union of Oncology
E AlexandrovaS Danon
Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland
O J O'ConnorH P Redmond
© 2022 Meta ULC. All rights reserved