Cyclooxygenase-2 expression in the normal human eye and its expression pattern in selected eye tumours

Acta Ophthalmologica
Jinmei WangM Kolko

Abstract

Cyclooxygenase-2 (COX-2) is an enzyme involved in neoplastic processes. The purpose of the present study is to investigate COX-2 expression in the normal human eye and the expression pattern in selected eye tumours involving COX-2 expressing cells. Immunohistochemical staining using antibodies against COX-2 was performed on paraffin sections of normal human eyes and selected eye tumours arising from cells expressing COX-2. Cyclooxygenase-2 expression was found in various structures of the normal eye. Abundant expression was seen in the cornea, iris, ciliary body and retina. The COX-2 expression was less in tumours deriving from the ciliary epithelium and also in retinoblastoma. Cyclooxygenase-2 is constitutively expressed in normal human eyes. The expression of COX-2 is much lower in selected eye tumours involving COX-2 expressing cells.

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Citations

Mar 1, 2011·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·L David WaterburyDavid A Hollander
Aug 7, 2013·Clinical Proteomics·Renu GoelAkhilesh Pandey
Jun 19, 2013·Survey of Ophthalmology·Rupali VohraMiriam Kolko
Feb 18, 2016·Neural Plasticity·Thomas SchwitzerVincent Laprevote
Oct 19, 2016·Acta Ophthalmologica·Ying ChangJost B Jonas
Feb 14, 2020·Metabolomics : Official Journal of the Metabolomic Society·Dmitry V ChistyakovEvgeni Yu Zernii
Apr 18, 2018·BMC Ophthalmology·Phillip S CoburnMichelle C Callegan
Jan 20, 2019·Current Topics in Medicinal Chemistry·Kamakshi DanduCh Mohan Rao
Feb 19, 2019·Neuroscience and Biobehavioral Reviews·Thomas SchwitzerVincent Laprevote

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