Abstract
In recent years it has become evident that tissue cyclooxygenase-2 (COX-2) may play a role in carcinogenesis and tumor malignancy. There is now a mounting body of information that strongly implies that COX-2 inhibitors may be of some value in the management of patients with carcinomas, and most recently several similar reports have appeared relating to sarcomas. The authors studied 32 samples of cartilage tumors from our tumor tissue bank for the presence of COX-2 by a Western blot technique. There were 29 patients from whom the samples were obtained, including 8 with enchondromas and 21 with chondrosarcomas. Thirteen of the 24 chondrosarcoma samples and none of the 8 enchondromas were positive for COX-2. An attempt was made to correlate these results with clinical data including age, gender, staging according to the Musculoskeletal Tumor Society, anatomical site, ploidic pattern, presence of metastases and death rate but no statistically valid correlation could be found. It is evident that COX-2 may play some role in chondrosarcoma but not in the benign enchondroma and that further studies with COX-2 inhibitors are warranted.
Citations
Jan 26, 2008·Nature Reviews. Cancer·Brian O Bodemann, Michael A White
May 25, 2010·Nature Reviews. Cancer·Christian C Naus, Dale W Laird
Dec 18, 2004·Current Opinion in Rheumatology·Jorge Casas-Ganem, John H Healey
Mar 9, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·L-S YehF-J Tsai
Jul 11, 2006·Journal of Clinical Pathology·Ako HosonoTadashi Hasegawa
Feb 12, 2014·PloS One·Michiyuki HakozakiHiroshi Hojo
Jun 5, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Francisco F CintraEliane M I Amstalden
Aug 27, 2009·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sung-Jig LimSung Il Choi
Aug 2, 2011·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xing DaiRajiv Kumar Jha
Oct 8, 2013·Hematology/oncology Clinics of North America·Jolieke G van OosterwijkJudith V M G Bovée
Nov 28, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C McCowanR J C Steele
Dec 17, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Y M SchrageJ V M G Bovée
Mar 6, 2012·Orthopedics·Andreas F MavrogenisPanayiotis J Papagelopoulos
Jun 8, 2011·Sarcoma·E DavidD Heymann
Mar 11, 2005·Journal of Cellular Biochemistry·Xinmin LiHali Wang
Oct 23, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Hüseyin Kemal TürközDeniz Ozcan
Oct 11, 2005·International Journal of Radiation Oncology, Biology, Physics·Fraser M SmithM John Kennedy
Sep 13, 2014·Korean Journal of Pathology·Hyun-Jin SonMee-Ja Park
Aug 2, 2005·The Lancet Oncology·Judith V M G BovéePancras C W Hogendoorn
Jan 12, 2011·Neurosurgery·Bujung HongMakoto Nakamura
May 19, 2021·Journal of the American Society for Mass Spectrometry·Rashmi MaddaWei-Ming Chen