PMID: 16507394Mar 2, 2006Paper

Cyclooxygenase-2 expression is associated with VEGF-C and lymph node metastases in gastric cancer patients

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
J ZhangY-Z Lin

Abstract

Previous studies have suggested that cyclooxygenase-2 (COX-2) over-expression is associated with angiogenesis in gastric cancer. However, the relationship between COX-2 and lymphangiogenesis is still unclear. The aim of this study was to determine the relationship between COX-2 expression and lymphangiogenic factor, vascular endothelial growth factor-C (VEGF-C), in human gastric cancer, as well as to correlate with clinicopathological parameters. Sixty-three gastric cancer patients underwent radical gastrectomy (D2 or D3) were enrolled in this study. The expression of COX-2 and VEGF-C were detected by immunohistochemistry, and the small lymphatic vessels were immunohistochemically stained by LYVE-1 antibody. The association between COX-2 and VEGF-C expressions and clinicopathological parameters (such as gender, tumor location, lymph node status and Lauren classification) were determined. VEGF-C over-expression was observed in 33 of 63 patients (52%), while COX-2 over-expression occurred in 42 of 63 tumor samples (67%). Presence of microlymphatic vessels with LYVE-1 staining was found in 35 cases. COX-2 over-expression was highly correlated with VEGF-C over-expression (P = 0.032), microlymphatic vessels (P = 0.002) as well as pr...Continue Reading

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Citations

Jan 29, 2011·Journal of Experimental & Clinical Cancer Research : CR·Hong-Feng GouMei Hou
Nov 26, 2013·Best Practice & Research. Clinical Anaesthesiology·Caroline P LeErica K Sloan
Apr 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei DaQun Sun
Oct 30, 2016·Journal of Clinical Laboratory Analysis·Poonam JawanjalGayatri Rath
Jun 28, 2016·Journal of the Egyptian National Cancer Institute·Nesreen H Hafez, Neveen S Tahoun
May 16, 2008·Journal of Cellular Physiology·Matthias Rinderknecht, Michael Detmar
Oct 24, 2007·Microvascular Research·Bernadette M M Zwaans, Diane R Bielenberg

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