Cyclooxygenase-2 expression, Ki-67 labeling index, and perifocal neovascularization in endometriotic lesions

Annals of Diagnostic Pathology
Lars-Christian HornCornelia Leo

Abstract

There is a suggested pathogenetic role of cyclooxygenase-2 (COX-2) in endometriosis via angiogenesis and proproliferative mechanisms. The aim of the study was to investigate the immunohistochemical COX-2 expression in different anatomical sites of endometriosis and its correlation to proliferative activity and periendometriotic vascularization. Sixty endometrioses from different sites (ovarian, uterine, and peritoneal) were evaluated immunohistochemically for COX-2 expression. Cyclooxygenase-2 staining of 75% or more of the cells was defined as COX-2 overexpression and used as cutoff. Proliferative activity was determined by performing Ki-67-labeling index. Periendometriotic vascularization was evaluated by determining microvessel density surrounding the endometriotic focus using CD-34-immunostaining. Cyclooxygenase-2 overexpression was significant more frequent in ovarian endometriosis, when compared with uterine and peritoneal localization (70.8% versus 41.7%; P = .027). There was no significant correlation between COX-2 overexpression and perifocal neovascularization (P = .49). Endometriotic lesions with COX-2 overexpression represented reduced proliferative activity (P = .055). Cyclooxygenase-2 is expressed in the majority ...Continue Reading

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Citations

Apr 27, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Carmen A HuniadiFlorin Stamatian
Jun 22, 2012·Human Reproduction Update·M W Laschke, M D Menger
Jun 23, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Alexandra MeinelLars-Christian Horn
Oct 9, 2012·Taiwanese Journal of Obstetrics & Gynecology·Inci KahyaogluSertac Batioglu

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