Cyclooxygenase-2 immunoexpression in intestinal epithelium and lamina propria of cats with inflammatory bowel disease and low grade alimentary lymphoma

BMC Veterinary Research
Jorge Castro-LópezJosep Pastor

Abstract

Cyclooxygenase 2 (COX-2) is an inducible isoform by cellular activation, proinflammatory cytokines and growth factors. The aims of the current study were to evaluate COX-2 immunoexpression in epithelial and lamina propria (LP) of cats with inflammatory bowel disease (IBD) and low grade alimentary lymphoma (LGAL), as well as to correlate them with clinical signs and histopathological scoring. Cats diagnosed with IBD and LGAL (2007-2013) were included in the current study. Feline chronic enteropathy activity index (FCEAI) was calculated for all cases. Control group was composed by 3 healthy indoor cats and 5 sick cats died or were euthanized (non-gastrointestinal illness). Diagnosis and classification of IBD and LGAL was established according to the WSAVA gastrointestinal standardization group template and the National Cancer Institute formulation, respectively. Furthermore, a modified WSAVA template was applied for LGAL evaluation. Immunolabelling for COX-2 (polyclonal rabbit anti-murine antibody) was performed on biopsy samples. Epithelial and LP (inflammatory or neoplastic cells) COX-2 immunolabelling was calculated according to the grade and intensity. The most representative segment scored by the WSAVA and the modified WSAVA...Continue Reading

References

May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Jan 12, 2000·Oncogene·C S WilliamsR N DuBois
May 7, 2002·Journal of the American Veterinary Medical Association·Michael D WillardJacque L Harbison
Jul 27, 2002·American Journal of Epidemiology·Elizabeth R BertoneAntony S Moore
Oct 14, 2003·The Veterinary Clinics of North America. Small Animal Practice·Keith P Richter
Apr 6, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S I MohammedD W Knapp
Sep 14, 2004·Leukemia & Lymphoma·Burhan HazarSibel Hakverdi
Dec 17, 2004·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·C PorcherK M Sanders
May 21, 2005·Toxicologic Pathology·Richard HaworthAndrew Pilling
Sep 6, 2006·Journal of Comparative Pathology·A HayesV Adams
Nov 18, 2006·The Journal of Biological Chemistry·Ying YuColin D Funk
Nov 24, 2006·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Shelley Joy Newman, Ladonna Mrkonjich
Feb 28, 2007·Leukemia & Lymphoma·Semra PaydasGulsah Seydaoglu
Jul 27, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A P R PaiottiM Franco
Jan 17, 2009·Arquivos De Gastroenterologia·Mônica RomeroMarcello Franco
Jul 7, 2009·Journal of Feline Medicine and Surgery·Amy E LingardVanessa R Barrs
Aug 28, 2009·European Journal of Clinical Pharmacology·Helenie KefalakesGeorge Kolios
Dec 17, 2009·Journal of Veterinary Internal Medicine·D Casamian-SorrosalM J Day
May 29, 2010·Pharmacological Reports : PR·Nilanjan GhoshSubhash C Mandal
Jun 30, 2010·Journal of Veterinary Internal Medicine·A E JergensC Wang
Dec 7, 2010·Journal of Feline Medicine and Surgery·Bianca StützerKatrin Hartmann
Mar 1, 2012·Journal of Feline Medicine and Surgery·Vanessa R Barrs, Julia A Beatty
Mar 1, 2012·Journal of Feline Medicine and Surgery·Vanessa R Barrs, Julia A Beatty
Jun 28, 2012·Journal of Feline Medicine and Surgery·Albert E Jergens
Sep 26, 2012·The Journal of Pharmacology and Experimental Therapeutics·Hiroshi SatohKoji Takeuchi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

SPSS
WSAVA
MWSAVA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
A P R PaiottiM Franco
The American Journal of Gastroenterology
J Hendel, O H Nielsen
© 2022 Meta ULC. All rights reserved