Cyclooxygenase-2 in rat nephron development

The American Journal of Physiology
M Z ZhangJ A McKanna

Abstract

The inducible second isoform of cyclooxygenase (COX-2) that mediates inflammation also is expressed at low levels in normal adult rat kidneys and is upregulated in response to noninflammatory stimuli (R. C. Harris, J. A. McKanna, Y. Akai, H. R. Jacobson, R. N. DuBois, and M. D. Breyer, J. Clin. Invest. 94: 2504-2510, 1994). Roles in morphogenesis are indicated by reported teratogenicity of COX inhibitors and renal dysgenesis in COX-2 knockout mice (J. E. Dinchuk, B. D. Car, R. J. Focht, J. J. Johnston, B. D. Jaffee, M. B. Covington, N. R. Contel, V. M. Eng, R. J. Collins, P. M. Czerniak, A. G. Stewart, and J. M. Trzaskos, Nature 378: 406-409, 1995; S. G. Morham, R. Lagenbach, C. D. Loftin, H. F. Tiano, N. Vouloumanos, J. C. Jennette, J. F. Mahler, K. D. Kluckman, A. Ledford, C. A. Lee, and O. Smithies. Cell 83: 473-482, 1995). Blots from developing rat kidneys demonstrated that COX-2 mRNA and immunoreactive protein were present in neonates, peaked in the 2nd and 3rd postnatal weeks and declined to adult levels by the 3rd month. Immunolocalization and in situ hybridization detected intense COX-2 immunoreactivity and mRNA in a subset of thick ascending limb epithelial cells near the macula densa in each developing nephron; after ...Continue Reading

References

Oct 1, 1992·American Journal of Reproductive Immunology : AJRI·A SchoenfeldY Ovadia
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L MasferrerP Needleman
Nov 1, 1990·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·J L Reyes, E Melendez
Sep 1, 1990·Hypertension·M Martínez-MaldonadoJ E Benabe
Jan 1, 1986·Annual Review of Biochemistry·P NeedlemanJ B Lefkowith
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D L DeWitt, W L Smith
Jan 1, 1985·Biology of the Neonate·D I MoelJ Penning
May 1, 1985·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·E D AvnerD Ellis
Mar 10, 1974·Prostaglandins·N A DayJ B Lee
Jan 1, 1980·Prostaglandins and Medicine·J M Moutquin, G C Liggins
Nov 1, 1981·Kidney International·J R MatsonJ E Robillard
Dec 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B S KaplanJ Bernstein
May 5, 1995·The Journal of Biological Chemistry·I MoritaW L Smith
Oct 1, 1994·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·L E VoyerJ H Méndez
Dec 1, 1994·The Journal of Clinical Investigation·R C HarrisM D Breyer
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J A MitchellJ R Vane
Apr 1, 1997·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J A McKanna, M Z Zhang

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Citations

Feb 22, 2001·American Journal of Physiology. Renal Physiology·H F ChengR C Harris
Nov 29, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Heather L MertzJames C Rose
Feb 1, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jane StubbeOle Skøtt
Jul 10, 2003·American Journal of Physiology. Renal Physiology·Ming-Zhi ZhangRaymond C Harris
Dec 23, 2004·American Journal of Physiology. Renal Physiology·Ming-Zhi ZhangRaymond C Harris
Sep 21, 2007·American Journal of Physiology. Renal Physiology·Haiying LiuTianxin Yang
Nov 9, 2007·Annual Review of Physiology·Chuan-Ming Hao, Matthew D Breyer
Sep 27, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·K MoritzE M Wintour
Jul 15, 2000·American Journal of Physiology. Renal Physiology·H F ChengR C Harris
Jul 14, 2004·Hypertension·Jorge A RodriguezNicholas R Ferreri
Jun 8, 2004·American Journal of Physiology. Renal Physiology·Frank SchwedaArmin Kurtz
Feb 12, 2004·American Journal of Physiology. Renal Physiology·Daina LasaitieneYun Chen
Mar 22, 2014·American Journal of Physiology. Renal Physiology·Ying LiuTianxin Yang
Jan 1, 2012·Pharmaceuticals·Francine G SmithWei Qi
Oct 1, 2019·European Journal of Pain : EJP·Daniel SegelckeEsther M Pogatzki-Zahn
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Ming-Zhi ZhangJames A McKanna
Dec 16, 2011·American Journal of Physiology. Renal Physiology·Shilin YangRaymond C Harris
Mar 27, 2003·American Journal of Physiology. Renal Physiology·Valentina CâmpeanSebastian Bachmann
Jun 16, 2001·American Journal of Physiology. Renal Physiology·R C Harris, M D Breyer
Dec 20, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Harold M AukemaMalcolm R Ogborn
Sep 2, 2011·American Journal of Physiology. Renal Physiology·Rikke NørregaardBoye L Jensen
Sep 18, 2003·American Journal of Physiology. Renal Physiology·Kirsten MadsenBoye L Jensen
Jan 14, 2009·Hypertension·Ming-Zhi ZhangRaymond C Harris
Jan 18, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Urja VermaSuresh Balakrishnan
Sep 20, 2019·Bio-protocol·Ming-Zhi Zhang, Raymond C Harris
Apr 6, 2021·The Journal of Veterinary Medical Science·Akira YabukiOsamu Yamato

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