PMID: 15239335Jul 9, 2004Paper

Cyclooxygenase 2 inhibitors and adenomatous polyposis coli

Bulletin du cancer
Christian Florent, Nathalie Meary

Abstract

Prolonged use of aspirin and/or non-steroidal anti-inflammatory drugs induces a partial regression of either sporadic adenomas or adenomas in adenomatous polyposis coli (APC), but also their emergence and colonic cancer development in sporadic adenomas. Specific inhibitors of cyclooxygenase of type 2 (Cox2) induce less upper and lower digestive tract adverse events that non-specific anti-inflammatory drugs. This better tolerance might allow a long-lasting use in patients with APC. At time, we don't know if such treatments are able to prevent the development of cancer in the rectum or duodenum of these patients. In this paper we will discuss the scientific proofs and potential interest of Cox2 inhibitors in the treatment of PAF.

Related Concepts

Related Feeds

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Related Papers

Bulletin du cancer
Christian Florent, Nathalie Meary
Lung Cancer : Journal of the International Association for the Study of Lung Cancer
C F QuirtL Ginsburg
Acta Oto-rhino-laryngologica Belgica
P Garin, A Frans
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
Małgorzata Dzielska-Olczak
© 2022 Meta ULC. All rights reserved