Cyclooxygenase-2 inhibitors: do they have a role in emergency department prescribing?

Emergency Medicine Australasia : EMA
Tanya Wilton

Abstract

Cyclooxygenase-2 selective inhibitors (COXIB or CSI) have been released with a fanfare as efficacious and safer alternatives to traditional non-steroidal anti-inflammatory drugs. They purport to offer equivalent degrees of analgesia and an improved safety profile. COXIB currently available in Australasia are celecoxib (Celebrex), rofecoxib (Vioxx) and etoricoxib (Arcoxia). This review discusses the pharmacology of these agents and reviews recent literature regarding their effectiveness and safety. It endeavours to answer the question 'Should we be using COXIB in emergency departments in Australasia'?

References

Mar 1, 1997·Neurology·W F StewartE J Metter
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T D WarnerJ R Vane
Jan 22, 2000·Arthritis and Rheumatism·L J CroffordL B van de Putte
Oct 21, 2000·Mayo Clinic Proceedings·N S Buttar, K K Wang
Nov 23, 2000·The New England Journal of Medicine·C BombardierUNKNOWN VIGOR Study Group
Feb 17, 2001·Clinical Pharmacology and Therapeutics·J I SchwartzB J Gertz
Jul 12, 2001·The Journal of Allergy and Clinical Immunology·D D Stevenson, R A Simon
Aug 11, 2001·The New England Journal of Medicine·G A FitzGerald, C Patrono
Sep 29, 2001·Obstetrics and Gynecology·M M SlatteryJ J Morrison
Oct 2, 2001·Pharmacology & Therapeutics·M LeszczynieckaP B Fisher
Dec 26, 2001·The New England Journal of Medicine·R R Schellenberg, S H Isserow
Jan 12, 2002·JAMA : the Journal of the American Medical Association·Gregory P GebaUNKNOWN Vioxx, Acetaminophen, Celecoxib Trial (VACT) Group
Jan 5, 2002·The New England Journal of Medicine·C M Nzerue
Jan 5, 2002·Gastroenterology Clinics of North America·L S Simon
Jan 5, 2002·Gastroenterology Clinics of North America·C J Hawkey, J I Jones
Apr 20, 2002·Science·John R Vane
Apr 20, 2002·Science·Yan ChengGarret A FitzGerald
May 15, 2002·The American Journal of Gastroenterology·Uma MahadevanWilliam J Sandborn
May 16, 2002·The Medical Journal of Australia·Martin B Van der Weyden
Jun 1, 2002·BMJ : British Medical Journal·Peter JüniPaul A Dieppe
Jun 22, 2002·BMJ : British Medical Journal·H Ralph SchumacherJavier Molina
Jul 12, 2002·Genetic Epidemiology·Richard SimonKevin Dobbin
Jul 24, 2002·BMJ : British Medical Journal·Muhammad MamdaniGeoffrey M Anderson
Sep 19, 2002·American Journal of Obstetrics and Gynecology·Catherine S StikaYoel Sadovsky
Oct 9, 2002·Current Medicinal Chemistry·C GridelliA Rossi
Oct 11, 2002·Proceedings of the National Academy of Sciences of the United States of America·Timothy D Warner, Jane A Mitchell
Nov 15, 2002·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·G Singh-Ranger, K Mokbel
Nov 30, 2002·BMJ : British Medical Journal·Gregory Y H LipNeeraj Prasad
Jan 9, 2003·Virchows Archiv : an International Journal of Pathology·UNKNOWN Association of Directors of Anatomic and Surgical Pathology
Feb 13, 2003·British Journal of Clinical Pharmacology·Deborah LaytonSaad A W Shakir
May 21, 2003·American Journal of Therapeutics·Nicole C Brazier, Mitchell A H Levine

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