Cyclooxygenase 2 is induced in colonic epithelial cells in inflammatory bowel disease

Gastroenterology
I I SingerWilliam F Stenson

Abstract

Prostaglandins are synthesized by cyclooxygenases (COX)-1 and -2. The expression and cellular localization of COX-1 and COX-2 in normal human colon and inflammatory bowel disease (IBD) surgical resections were studied. COX-1 and COX-2 protein expression and cellular localization were assessed by Western blotting and immunohistochemistry. COX-1 protein was expressed at equal levels in normal, Crohn's disease, and ulcerative colitis colonic epithelial cells. COX-2 protein was not detected in normal epithelial cells but was detected in Crohn's disease and ulcerative colitis epithelial cells. Immunohistochemistry of normal, Crohn's colitis, and ulcerative colitis tissue showed equivalent COX-1 expression in epithelial cells in the lower half of the colonic crypts. COX-2 expression was absent from normal colon, whereas in Crohn's colitis and ulcerative colitis, COX-2 was observed in apical epithelial cells and in lamina propria mononuclear cells. In Crohn's ileitis, COX-2 was present in the villus epithelial cells. In ulcerative colitis, colonic epithelial cells expressing COX-2 also expressed inducible nitric oxide synthase. COX-1 was localized in the crypt epithelium of the normal ileum and colon, and its expression was unchanged ...Continue Reading

References

Nov 1, 1985·The Journal of Clinical Investigation·A WeymerK Dharmsathaphorn
May 1, 1994·The Journal of Clinical Investigation·D SalveminiP Needleman
Nov 1, 1995·Digestive Diseases and Sciences·A UribeM Winell-Kapraali
Jul 1, 1995·Gastroenterology·C E Eberhart, R N Dubois
Jul 1, 1996·The Journal of Clinical Investigation·S J McKenzieW F Doe
Nov 1, 1996·The Journal of Clinical Investigation·B K ReuterJ L Wallace

Citations

Jan 22, 2000·Arthritis and Rheumatism·L J CroffordL B van de Putte
Jan 19, 2007·Inflammatory Bowel Diseases·James JuppAnthony P Sampson
Sep 26, 2008·Inflammatory Bowel Diseases·William F Stenson
Apr 3, 2012·Inflammatory Bowel Diseases·George P ChristophiSteve K Landas
May 4, 2005·Diseases of the Colon and Rectum·Farshad AbirWalter E Longo
Jan 2, 2007·Diseases of the Colon and Rectum·Marco RomanoFrancesco Selvaggi
Jan 18, 2006·Digestive Diseases and Sciences·Angela M MeyerJonathan A Leighton
Apr 15, 2006·Digestive Diseases and Sciences·Martin KruschewskiChristoph Loddenkemper
Jun 27, 2008·Pharmaceutical Research·Afraa ZriekiMarion Buyse
Dec 3, 2003·European Journal of Pharmacology·Antonio MartínCatalina Alarcón de la Lastra
Jun 27, 2000·Prostaglandins & Other Lipid Mediators·B Mohajer, T Y Ma
Jun 27, 2000·Prostaglandins & Other Lipid Mediators·W Krause, R N Dubois
Nov 16, 2002·Prostaglandins & Other Lipid Mediators·Naoki KawaiShingo Tsuji
Mar 21, 2000·Biochimica Et Biophysica Acta·S M Prescott, F A Fitzpatrick
Jan 5, 2002·Gastroenterology Clinics of North America·J L Wallace
Mar 10, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·F Marks, G Fürstenberger
Sep 5, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Giovanna CipollaGianmario Frigo
Dec 17, 2003·Prostaglandins & Other Lipid Mediators·C Y YangP Y K Wong
Sep 20, 2001·International Immunopharmacology·F A Fitzpatrick
Dec 1, 2009·Oncogene·Dingzhi Wang, R N Dubois
Sep 1, 1999·Alimentary Pharmacology & Therapeutics·S A McCartneyT D Warner
Aug 31, 2002·Journal of Gastroenterology and Hepatology·Isao OkayasuToshifumi Ohkusa
Oct 5, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N HayashiM Monden
Nov 15, 2008·Nutrition and Cancer·Takuji TanakaTakeru Oyama
Mar 10, 2001·Antioxidants & Redox Signaling·C M PayneH Garewal
Feb 9, 2012·Journal of the National Cancer Institute·Dingzhi Wang, R N Dubois
Sep 26, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ashley J SniderLina M Obeid
May 24, 2001·Annals of Surgery·D H ChungB M Evers
Oct 7, 2006·Current Opinion in Gastroenterology·Courtney W Houchen, William F Stenson
Oct 7, 2006·Current Opinion in Gastroenterology·J A KatzClaudio Fiocchi
Feb 11, 2005·Current Opinion in Gastroenterology·William F Stenson
Jul 20, 2002·Pancreas·Wolfgang SchlosserHans-Günter Beger
Aug 7, 2003·Inflammatory Bowel Diseases·Refaat A F HegaziHossam M Kandil
Mar 15, 2006·Inflammatory Bowel Diseases·Claudia Reinhard, John D Rioux
Dec 12, 2012·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Yan JiangSuzanna M Zick
Jan 19, 2013·Inflammatory Bowel Diseases·Rachel Marion-LetellierSubrata Ghosh
Feb 3, 2007·Current Opinion in Gastroenterology·William F Stenson
Apr 20, 2005·Journal of Gastroenterology and Hepatology·Zhuobin ZhangYoshihide Fujiyama
May 11, 2005·Kidney International·Teemu HonkanenI Rantala
Jan 13, 2009·Clinical Microbiology Reviews·Julien Santi-RoccaNancy Guillén
Apr 9, 2001·Infection and Immunity·William F StensonS L Stanley
May 31, 2003·Canadian Journal of Physiology and Pharmacology·E Eklou-KalonjiF Blachier
May 14, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stuart S HobbsD Brent Polk
Apr 3, 2002·The Journal of Clinical Investigation·Kenji KabashimaShuh Narumiya
May 8, 2001·Journal of Periodontology·R S Morton, A I Dongari-Bagtzoglou
Oct 3, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·J A Oviedo, M M Wolfe
Aug 27, 2013·International Journal of Molecular Sciences·Sally TemrazAli Shamseddine
May 14, 2008·World Journal of Gastroenterology : WJG·Luis G GuijarroAmado-Salvador Pena
Jan 29, 2011·World Journal of Gastroenterology : WJG·David PhilippeStéphanie Blum
Apr 20, 2012·Immunotherapy·Maximilian J Waldner, Markus F Neurath
Oct 31, 2003·Proceedings of the National Academy of Sciences of the United States of America·Indranil DeyKris Chadee
Feb 10, 2000·The American Journal of Pathology·K S ChappleM A Hull
Aug 20, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Francesca BorrelliAngelo A Izzo
Apr 26, 2014·Proceedings of the National Academy of Sciences of the United States of America·Dingzhi WangR N Dubois
Oct 2, 2012·Annual Review of Medicine·Dingzhi Wang, R N Dubois
Nov 27, 2009·Journal of Molecular Histology·A P R PaiottiM Franco
Jul 6, 2014·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Mette BoydAlbin Sandelin
Nov 22, 2012·European Journal of Gastroenterology & Hepatology·Samy A Azer
Apr 13, 2007·Digestive Diseases and Sciences·Mitsuaki OkayamaKoji Takeuchi
Sep 18, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Sourav ChattopadhyaySomenath Roy
Dec 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Hyun Jung KimDonald E Ingber
Jul 26, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Aleksandra Malgorzata UrbanskaSatya Prakash
Apr 15, 2015·Journal of the Science of Food and Agriculture·Ahlem BoussennaCatherine Felgines
Jan 18, 2016·European Journal of Medicinal Chemistry·Marco MiglioreRita Scarpelli
Feb 6, 2013·Prostaglandins & Other Lipid Mediators·Lauren L NicotraScott D Smid
Jun 13, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Noha Ahmed Nasef, Lynnette R Ferguson
Dec 2, 2008·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Yulyana YudinaAnita Sjölander
Jun 21, 2008·Research in Veterinary Science·Alessandro MenozziSimone Bertini
Apr 15, 2008·Cancer Letters·Dingzhi Wang, R N Dubois
Jun 3, 2008·Biochimica Et Biophysica Acta·Hung PhamLee W Slice
Mar 22, 2007·European Journal of Pharmacology·Susana Sánchez-FidalgoCatalina Alarcón de la Lastra
Jul 15, 2009·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Signe WildtMiriam Kolko
Feb 14, 2007·American Journal of Reproductive Immunology : AJRI·Fumihisa ChishimaNorimichi Nemoto
Jun 15, 2007·Journal of Cellular Physiology·Hung PhamLee W Slice
Jun 15, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K SatoHiroshi Ozaki
Oct 6, 2005·International Journal of Cancer. Journal International Du Cancer·Tsutomu YoshidaIsao Okayasu
Oct 14, 2006·Molecular Nutrition & Food Research·Jürgen SchauberWolfgang Scheppach
Jan 5, 2011·Journal of Cellular and Molecular Medicine·Min ChenJean-Louis Guéant
Jan 30, 2014·International Journal of Cancer. Journal International Du Cancer·Masahito ShimizuHisataka Moriwaki
Oct 2, 2014·Journal of Veterinary Internal Medicine·S D DumuscI A Burgener
Feb 21, 2016·Journal of Crohn's & Colitis·Ilse MolendijkHein W Verspaget
Oct 31, 2006·European Journal of Pharmacology·Alessandro MenozziGabriella Coruzzi
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·D CamuescoJ Gálvez
Oct 6, 2005·Biochemical and Biophysical Research Communications·Ki Han KwonHajime Ohigashi
Aug 22, 2006·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N BernardiniC Blandizzi
Jul 24, 2010·British Journal of Pharmacology·R López-PosadasFermín Sánchez de Medina
Dec 4, 2010·Biochimica Et Biophysica Acta·Mehmet CoskunOle Haagen Nielsen
Aug 8, 2015·European Journal of Nutrition·K Vijay Kumar Reddy, K Akhilender Naidu
May 5, 2001·Expert Opinion on Pharmacotherapy·A Ballinger, G Smith
Mar 10, 2001·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·K Takeuchi, A Tanaka
Aug 2, 2003·The Journal of the American Dental Association·Fan ZhangAndrew J Dannenberg
Jul 30, 2014·Gut and Liver·Eun-Kyoung ParkHae Soo Koo
Jun 3, 2011·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Ayman IbrahimRachel Marion-Letellier
Apr 14, 2015·BioMed Research International·Atsukazu Kuwahara
Feb 24, 2009·Biochemical and Biophysical Research Communications·Eun Kyung ShinJin-Kyung Kim
Jan 31, 2002·Annual Review of Medicine·Marco E Turini, R N Dubois
Sep 22, 2001·Best Practice & Research. Clinical Gastroenterology·K E Giercksky
Nov 14, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·Enzo SpisniAntonio Strillacci
Jan 23, 2016·Expert Review of Gastroenterology & Hepatology·Mohammad Hosein FarzaeiNima Rezaei
Sep 12, 2000·The American Journal of Pathology·S N AgoffMary P Bronner
Aug 19, 2000·The American Journal of Gastroenterology·G F BonnerM Bayona
Apr 22, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jacqueline Van De WalleYves-Jacques Schneider
Feb 18, 2016·Journal of Gastroenterology and Hepatology·Hye-Youn KimSuntaek Hong
Mar 21, 2001·Critical Reviews in Clinical Laboratory Sciences·R J FarrellM A Peppercorn
Jan 10, 2017·Food & Function·Carla NunesJoão Laranjinha
Apr 14, 2016·Annals of Surgery·Kostan W ReisingerMartijn Poeze
Jan 17, 2009·Arquivos De Gastroenterologia·Mônica RomeroM Franco
Jul 27, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A P R PaiottiM Franco
Apr 6, 2006·Journal of Lipid Research·Raquel Martín-VenegasJuan José Moreno
Jun 30, 2017·The American Journal of Chinese Medicine·Dae-Seung KimSeung-Heon Hong
Apr 12, 2010·Pharmaceuticals·Amir Klein, Rami Eliakim
Dec 6, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mohammad A AlzoghaibiMartin F Graham
Apr 24, 2001·The American Journal of Gastroenterology·G F Bonner
Mar 27, 2004·Alimentary Pharmacology & Therapeutics·L BianconeF Pallone
Dec 21, 2002·The American Journal of Gastroenterology·Jean-Mar GornetMarc Lémann
May 15, 2002·The American Journal of Gastroenterology·Uma MahadevanWilliam J Sandborn
Jul 16, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·B StoffelsR H Tolba
Jun 30, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mark R FreyD Brent Polk
Mar 10, 2011·The American Journal of Gastroenterology·Gati A GoelBret Lashner
Aug 19, 2000·The American Journal of Gastroenterology·J O'Brien
Oct 20, 2005·Clinical and Experimental Immunology·S C MillsS C Knight
May 6, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Theresa F WuPierre-Yves von der Weid
Mar 7, 2002·American Journal of Physiology. Cell Physiology·R C MifflinDon W Powell
Sep 8, 2018·The Journal of Pharmacology and Experimental Therapeutics·Elizabeth H FernandoWallace K MacNaughton
Feb 28, 2002·The Journal of Pharmacology and Experimental Therapeutics·Akiko TanakaKoji Takeuchi
May 16, 2006·The Journal of Pharmacology and Experimental Therapeutics·Ryo HatazawaKoji Takeuchi
Aug 27, 2005·The Journal of Pharmacology and Experimental Therapeutics·Debora PorathJoseph Schwager
May 31, 2019·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rajendra SangarajuRamakrishna Sistla
Oct 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ewa ŻyłaJoanna Gromadzka-Ostrowska
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michelle C BuresiWallace K MacNaughton
Nov 23, 2007·Biochemical Society Transactions·M Fukata, M T Abreu
Jan 31, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Izumi KajiAtsukazu Kuwahara
Jul 11, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Chunyan WangLi Zhang
Mar 12, 2015·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Oscar SassoDaniele Piomelli
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yutaka HosodaAtsukazu Kuwahara
Aug 23, 2019·World Journal of Gastroenterology : WJG·Hilda Vargas-RoblesMichael Schnoor
Apr 17, 2020·Frontiers in Bioengineering and Biotechnology·Maria BarraDaniel Garrido
Mar 19, 2003·Alimentary Pharmacology & Therapeutics·M H Gleeson, A J M Davis
Aug 13, 1999·The American Journal of Physiology·J BeltingerY R Mahida
Jun 2, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J M MeiJ M Phang
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·Courtney W HouchenS M Cohn
Apr 9, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·A J KirkupD Grundy
May 21, 2003·International Journal of Dermatology·Kathleen J Smith, Henry Skelton
Apr 8, 2004·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kouhei Fukushima, Claudio Fiocchi
Oct 1, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Taisuke OtaniAndrew J Dannenberg
Sep 8, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emilie DegagnéFernand-Pierre Gendron
Mar 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Junji WatanabeSrinivasa T Reddy
Jul 15, 2020·Critical Reviews in Food Science and Nutrition·Ningning HuangHongkui Wei
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·D S HanR B Sartor
Nov 15, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Courtney W HouchenWilliam F Stenson
Feb 18, 2006·The Journal of Nutrition·Abdelali DaddaouaOlga Martínez-Augustin
Dec 5, 2006·World Journal of Gastroenterology : WJG·Chun-Mei Xu, Chuan-Hu Qiao
Dec 23, 2017·Journal of Cellular and Molecular Medicine·Soudamani SinghUma Sundaram
Aug 24, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·O KobayashiN Sato
Mar 21, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kazuya KinoshitaHideaki Karaki
Dec 11, 2014·World Journal of Gastroenterology : WJG·Ru ChenTeresa A Brentnall
Oct 11, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hilal AhmadVijay L Kumar
Apr 1, 2005·World Journal of Gastroenterology : WJG·Terence-C TangSheung-Tat Fan
Oct 1, 2010·The Journal of Nutrition·Rocío López-PosadasOlga Martínez-Augustin
Oct 5, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Laura E FredenburghMark A Perrella
Jun 22, 2017·Scientific Reports·Manish Kumar JeengarSrinivas Uppugunduri
Aug 13, 1999·The American Journal of Physiology·D W PowellA B West
Aug 4, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ryo HatazawaKoji Takeuchi
Mar 16, 2018·Journal of Biomedical Science·Yu-Ju PengShih-Torng Ding
Mar 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Leah B SansburyElaine Lanza
Sep 1, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Štefan TóthPeter Kruzliak
Jan 28, 2021·International Journal of Molecular Sciences·Giulia CaioniElisabetta Benedetti

Related Concepts

PTGS1 protein, human
Prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase), human
Colitis
Ulcerative Colitis
Taenia Coli
IIeocolitis
Enzyme Induction
Ileitis
Structure of Intestinal Gland
Alloenzymes

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.