Cyclooxygenase-2 modulates the insulin-like growth factor axis in non-small-cell lung cancer

Cancer Research
Mehis PõldSteven M Dubinett

Abstract

Constitutive overexpression of cyclooxygenase-2 (COX-2) occurs frequently in several different malignancies, including lung, colon, breast, and prostate cancer. Clinical studies have established elevated serum insulin-like growth factor (IGF-I) content and IGF-I:IGF-binding protein 3 (IGFBP-3) ratio as risk factors for these same malignancies. Therefore, we sought to determine the link between COX-2 expression and the IGF axis in COX-2 gene-modified human non-small-cell lung cancer (NSCLC) cells. Overexpression of COX-2 in NSCLC cells enhanced the antiapoptotic and mitogenic effects of IGF-I and IGF-II, facilitated the autophosphorylation of the type 1 IGF receptor, increased class IA phosphatidylinositol 3'-kinase activity, and decreased expression of IGFBP-3. Thus, these findings show that COX-2 augments the stimulatory arm of the IGF axis.

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Citations

Oct 22, 2011·Cancer Metastasis Reviews·Naveena B JanakiramChinthalapally V Rao
Apr 19, 2011·Seminars in Respiratory and Critical Care Medicine·Brigitte N GompertsSteven M Dubinett
Apr 1, 2006·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Marina UlanovaA Dean Befus
Jan 15, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Frank Michael KlenkeAxel Sckell
Aug 16, 2005·Clinical Lung Cancer·Jenny T MaoSteven M Dubinett
Jul 18, 2006·Biochimica Et Biophysica Acta·Raushan T Kurmasheva, Peter J Houghton
Nov 23, 2005·Biochemical and Biophysical Research Communications·Pei-Shan ChienHao-Jen Huang
May 6, 2015·Journal of Clinical and Experimental Hepatology·Magda HamzawyNivin Sharawy
May 12, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Fred R Hirsch, Scott M Lippman
Nov 11, 2006·International Journal of Cancer. Journal International Du Cancer·Masakazu YashiroKosei Hirakawa
Apr 5, 2008·International Journal of Cancer. Journal International Du Cancer·Yi CaiChawnshang Chang
Jun 28, 2020·FEBS Open Bio·Sadaf DorandishHedeel Guy Evans
Jan 14, 2009·Cancer Prevention Research·Steven M DubinettSaswati Hazra

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